Early Red Blood Cell Transfusion Strategy in Septic Shock Among Cancer Patients: Insights from the TRANSPORT Randomized Controlled Trial

Highlights

• The TRANSPORT trial is a multicenter randomized controlled study focusing on red blood cell transfusion strategies in cancer patients with septic shock.
• No superiority of liberal (hemoglobin threshold 9.0 g/dL) compared to restrictive (threshold 7.0 g/dL) transfusion was demonstrated in terms of 12-hour lactate reduction or 28-day mortality.
• Liberal transfusion was associated with significantly increased arterial and venous thrombotic events.
• Evidence supports no routine preference for either transfusion strategy; individualized clinical decisions are necessary.

Background