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In women with chronic severe coronary artery disease, CABG was linked to lower long-term rates of death, stroke, heart attack, repeat revascularization, and cardiovascular readmission than PCI.
Pembrolizumab plus chemoradiotherapy improved survival and quality-adjusted survival for FIGO 2014 stage III-IVA cervical cancer and was projected to be cost-effective in the U.S. at a $150,000/QALY threshold.
This study links PCOS-related miscarriage risk to gut microbiome changes, especially reduced Parabacteroides merdae and higher isoleucine, which may promote endometrial senescence and impair pregnancy outcomes.
Hospitals that serve more Black patients had higher rates of trial of labor after cesarean and VBAC success among low-risk patients, suggesting hospital practices may influence cesarean-related disparities.
A Danish multicenter study found that adding HE4 to the IOTA ADNEX model offered only limited, threshold-dependent benefit for assessing adnexal masses, with no meaningful improvement in non-tertiary centers.
A randomized trial found vaginal assisted NOTES hysterectomy improved same-day discharge, operative time, and blood loss versus standard vaginal hysterectomy, without increasing complications or affecting recovery.
A U.S. national study found endometriosis surgery is shifting from inpatient to outpatient care, with hospital cases more common in older, medically complex patients and those with more extensive disease.
Severe surgical complications during cesarean delivery were linked to about twice the risk of postpartum readmission within 42 days, especially for wound infection, supporting closer follow-up after complicated births.
A large real-world registry study shows that ovarian cancer patients aged 70 and older still carry clinically actionable germline variants, often without a reported family history, supporting broader age-inclusive genetic testing.
A large Australian longitudinal study found that women with both hot flushes and night sweats had slightly higher odds of retirement, suggesting menopausal symptom burden may influence workforce participation.
This review synthesizes contemporary evidence on the duration of active pushing, highlighting how epidural use, fetal malposition, and parity influence the probability of spontaneous delivery and maternal-neonatal outcomes.
A randomized trial found that 6 hours of intrauterine balloon tamponade was noninferior to 18 hours for controlling postpartum hemorrhage after vaginal delivery, suggesting earlier removal may be reasonable in stable patients.
A clinical trial found that weekly extended-release buprenorphine significantly improves illicit opioid abstinence during pregnancy compared to sublingual forms, with fewer serious adverse events, offering a safer treatment option for opioi
Study shows post-diagnosis estrogen therapy improves survival in high-grade serous and clear cell ovarian cancers but may worsen outcomes in endometrioid subtypes, offering guidance for managing menopausal symptoms in younger survivors.
In this post hoc analysis of a large randomized pregnancy trial, aspirin’s effects on preterm birth and perinatal mortality were not meaningfully modified by gestational age at initiation or measured adherence.
A large prospective cohort suggests that long-term sequelae of congenital CMV after primary maternal infection are confined to first-trimester exposure, with autism spectrum disorder linked to temporal lobe white matter abnormalities.
A US cohort study of 543 ovarian cancer patients revealed 37% experienced decreased platelets during niraparib maintenance. Onset typically occurred within 1 month but resolved rapidly with dose adjustments, resulting in low discontinuation
A retrospective UK study of 24,334 pregnancies developed predictive models for shoulder dystocia and birth trauma using maternal characteristics and fetal abdominal circumference, showing improved accuracy over current methods.
Study reveals inadequate hemoglobin improvement at 20-24 weeks after iron therapy increases stillbirth and preterm birth risks in moderate iron deficiency anemia pregnancies, highlighting need for early intervention.
A narrative review suggests HPV self-sampling is acceptable and potentially practice-changing for transmasculine and nonbinary people who are often underscreened for cervical cancer.
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