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Readmissions following chronic/subacute subdural hematoma hospitalizations are common and mostly nonsurgical, with varied clinical trajectories. Machine learning analysis reveals distinct patient clusters with unique readmission risks, unde
The phase 3 TEMPO-2 trial demonstrates that flexible-dose tavapadon, a selective D1/D5 dopamine receptor agonist, significantly improves motor symptoms in early Parkinson’s disease with a manageable safety profile, warranting further
Highlight Deep learning applied to 12-lead ECG signals enables estimation of 10-year ischemic stroke risk with moderate discrimination and good calibr
Inflammatory blood biomarkers consistently predict long-term recurrent stroke risk up to 10 years post-event, independent of traditional vascular risk factors, underscoring the potential for anti-inflammatory secondary prevention strategies
This review explores the role of dysregulated iron metabolism and inflammation, particularly elevated serum ferritin, in isolated REM sleep behavior disorder (iRBD) as a prodromal stage of neurodegeneration, synthesizing recent longitudinal
Automated speech analysis of brief connected speech accurately identifies clinical, anatomical, and neuropathological variants of primary progressive aphasia, facilitating scalable diagnosis and monitoring.
This review synthesizes international evidence on survival in genetic frontotemporal dementia (FTD), highlighting key predictors such as age at onset, clinical phenotype, and motor symptoms, and discusses implications for patient care and t
This retrospective analysis reveals that standard antiplatelet therapy may reduce mortality compared to thrombolysis in acute spontaneous spinal cord infarction, highlighting the need for cautious therapeutic decisions pending stronger evid
The VasCog-2-WSO criteria effectively detect MRI-defined vascular cognitive impairment in asymptomatic adults, correlating with increased cardiovascular risk and mortality, highlighting their utility for early diagnosis and community risk s
Serum GFAP elevation predicts progression independent of relapse in MS; therapy-induced GFAP reduction associates with decreased progression risk, supporting GFAP as a biomarker for progression risk stratification and treatment monitoring.
This review synthesizes evidence from a large-scale multi-ancestry study revealing ancestry-specific distributions of Parkinson’s disease genetic variants, emphasizing the need for diverse population inclusion to optimize diagnosis an
This study identifies key prognostic factors and proposes a graded prognostic assessment to stratify survival in patients with brain metastases from nonanaplastic follicular cell-derived thyroid carcinoma.
Intensive blood pressure lowering post-thrombectomy increases acute kidney injury risk, which correlates with poorer neurological outcomes in stroke patients. Careful BP management is crucial to prevent renal complications and optimize reco
This study identifies distinct sleep patterns linked to cognitive performance but finds no significant direct association with dementia risk, highlighting the complexity of sleep-cognition relationships in aging populations.
A 10-year-old with a midbrain ischemic lesion after craniopharyngioma resection developed mutism with features of both akinetic mutism and cerebellar mutism, suggesting a shared neurocircuitry that responded to methylphenidate.
A systematic review and meta-analysis of 18 RCTs found that high-intensity resistance training significantly improved leg press and extension strength in adults aged 50+ compared to low-moderate intensity, with similar effects on bone density and no significant difference in fall incidence or adverse events.
A secondary analysis of the INTERACT3 trial shows that younger adults (≤50 years) with intracerebral hemorrhage have lower mortality and disability but differ in risk factors and may benefit more from bundled care.
A metabolomic clock based on plasma metabolites accurately estimated chronological age (r=0.92) and was associated with mortality, frailty, and cognitive impairment across two European cohorts.
Among older adults with incident dementia, Alzheimer disease and LATE-NC pathologies were independently linked to higher odds of receiving a timely diagnosis, while vascular pathology and Lewy bodies showed no significant association.
The phase 3b TEMPLE trial found that atogepant 60 mg once daily led to fewer discontinuations due to adverse events and better migraine reduction than topiramate over 24 weeks.
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