Recent Mechanical Venous Thrombosis Risk Factors and Their Role in Young-Onset Cryptogenic Ischemic Stroke: New Insights from the SECRETO Study

Highlight

• Recent mechanical risk factors for venous thrombosis occurring within 14 days before stroke are independently associated with young-onset cryptogenic ischemic stroke (CIS).
• This association is strongest in adults aged 18 to 39 and is accentuated in the presence of a clinically relevant patent foramen ovale (PFO).
• Mechanical risk factors occurring beyond 14 days prior do not show a significant association, and thrombophilia markers do not explain this risk.
• The findings highlight the need for thorough assessment of recent mechanical venous thrombosis triggers and potential PFO screening in young cryptogenic stroke patients.

Study Background