Section
This review synthesizes evidence on the feasibility, acceptance, and clinical outcomes of pulmonary telerehabilitation models in COPD, highlighting technical reliability, patient adherence, and clinical benefits from recent trials, includin
GLP-1 receptor agonists exhibit promising osteoprotective and anti-inflammatory effects in preclinical dental studies but lack robust clinical data, underscoring urgent research needs on their oral health impact and safety profile.
A Phase 3b trial in eastern and southern Africa showed that long-acting injectable cabotegravir plus rilpivirine is noninferior to oral dolutegravir-based therapy for maintaining viral suppression in HIV patients facing adherence challenges
The PERSONA-Ovary trial demonstrates the feasibility and clinical value of unselected germline multigene panel testing alongside somatic BRCA analysis in ovarian carcinoma, revealing a 29.7% pathogenic variant prevalence and optimal testing
This study confirms the K-Force grip dynamometer as a responsive tool to detect short-term changes in handgrip strength in ICU-acquired weakness patients, supporting its clinical utility in critical care rehabilitation.
The LATA trial demonstrates that long-acting injectable cabotegravir-rilpivirine given every 8 weeks is superior to daily oral ART for maintaining virological suppression in adolescents with HIV in sub-Saharan Africa, with a favorable safet
In children with medical complexity hospitalized for nonsevere community-acquired pneumonia, broad-spectrum antibiotics show no advantage over narrow-spectrum agents, supporting targeted aminopenicillin use to improve outcomes and antibioti
This article explores the differential associations of mosaic chromosomal alterations (mCAs), especially chromosomal loss and mosaic loss of the X chromosome, with systemic sclerosis and its subtypes, revealing phenotype-specific genetic co
Prolonged donor warm ischemia during pure laparoscopic donor right hepatectomy elevates recipient biliary stricture risk, underscoring the need to minimize warm ischemic time for better post-transplant outcomes.
The COMPASS-SCC, developed from a large international cohort, offers improved prognostic accuracy for cutaneous squamous cell carcinoma compared to existing AJCC8 and BWH staging systems, aiding clinical decision-making for metastasis and m
This study shows that prior implant-based reconstruction combined with radiotherapy increases perioperative microvascular complications but not flap necrosis in delayed DIEP flap breast reconstruction, highlighting increased surgical comple
This article reviews a large retrospective study revealing significant associations between CYP2D6 and CYP2C19 genotypes and venlafaxine treatment failure, highlighting the potential for genotype-guided personalized antidepressant therapy.
Higher cumulative inotropic exposure during VA ECMO support in cardiogenic shock is associated with increased risk of ECMO weaning failure, mortality, arrhythmias, and delayed lactate clearance, highlighting the need for prospective trials
Standardizing outpatient documentation significantly reduces internal medicine resident time spent on EHR tasks and excessive note lengths, with modest improvements in burnout measures despite no broad well-being changes observed.
Factor XI-targeted antibodies, amrecibart and cenvacibart, offer promising anticoagulation by selectively inhibiting intrinsic coagulation pathways, potentially reducing thrombosis without increasing bleeding risk.
The ENCORE trial demonstrates that amikacin liposome inhalation suspension combined with multidrug therapy improves respiratory symptoms and culture conversion in newly diagnosed Mycobacterium avium complex lung disease patients.
A multisociety task force finds routine high-level disinfection (HLD) of reusable ophthalmic devices unnecessary in most clinics, recommends targeted HLD only for higher-risk encounters, and urges alignment of regulations with evidence.
This study explores the association between inducible laryngeal obstruction (ILO) and symptoms in patients with hypermobile Ehlers-Danlos syndrome (hEDS) and hypermobility spectrum disorders (HSD), highlighting chronic cough, dysphagia, and
Omission of sentinel lymph node biopsy (SLNB) in select postmenopausal patients with early HR+/HER2- breast cancer and negative axillary ultrasound is feasible and safe, reducing surgical morbidity without compromising short-term outcomes.
Antenatal oxytocin combined with dexamethasone significantly improves respiratory adaptation and reduces adverse outcomes in late-preterm lambs delivered by cesarean section, highlighting potential novel preventive strategies for neonatal r
