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Rare coding variants in the FOXF1 gene are linked to pulmonary arterial hypertension (PAH), implicating impaired endothelial FOXF1 expression and disrupted BMPR2 regulation in disease development.
More than one-third of Hispanic/Latino adults with diabetes exhibit diabetic retinopathy (DR), with significant variability across backgrounds. Hypertension notably associates with DR and vision-threatening DR, highlighting the need for tar
Combining FIESTA-C and MENSA MRI sequences improves visualization of the facial nerve and tumor localization in parotid gland surgery, potentially reducing facial nerve palsy risk.
This article analyzes FDA-approved surgical AI devices, highlighting trends in technology, evidence quality, regulatory pathways, and implications for clinical adoption.
A randomized trial demonstrates that a patient-facing educational website improves contraceptive knowledge and perceived access more effectively than standard federal consent materials among individuals considering tubal sterilization.
This article explores how the zinc-dependent RNA-binding protein ZFP36L1 controls hepatocyte senescence and influences recovery from alcohol-related liver failure by modulating key mRNAs, highlighting its potential as a therapeutic target i
This pooled analysis of INTERACT and ATACH-II trials reveals that intensive blood pressure lowering significantly improves outcomes only in patients with deep intracerebral hemorrhage, highlighting hematoma location as crucial for personali
The twiist AID system significantly improves glycemic control and patient satisfaction in insulin-treated type 2 diabetes over 13 weeks, demonstrating safety and effectiveness supported by complementary real-world and RCT data.
This article explores how palmitic acid induces a pro-hypertrophic memory in cardiomyocytes through epigenetic regulation involving KDM5A and H3K4me3 modifications, driving cardiac hypertrophy and heart failure, and highlights potential the
Office-based vergence/accommodative therapy with movement (OBVAM) significantly improves accommodative amplitude and facility in adolescents and young adults with concussion-related convergence insufficiency, accelerating recovery and funct
This RCT demonstrates that high-intensity laser therapy combined with ulnar nerve gliding exercises yields superior electrophysiological and functional recovery in post-burn cubital tunnel syndrome compared to shock wave therapy or exercise
A novel deep learning model significantly improves diagnostic accuracy in distinguishing fibro-osseous jaw lesions (FD, COF, COD) from histology images, outperforming expert pathologists and offering a promising diagnostic support tool.
A large randomized trial finds no difference in 90-day days alive and out of hospital between early vasopressors with restricted fluids versus higher fluids with delayed vasopressors in septic shock, though pulmonary edema was less frequent
This article discusses the development and validation of a concise Norwegian tool to assess social cognition deficits in traumatic brain injury patients, maintaining reliability and clinical feasibility compared to the full version.
This study evaluates wound healing and pain outcomes among PRF, PRGF, collagen-based dressing, and spontaneous healing in standardized palatal defects, revealing minimal added benefit from adjunctive treatments in healthy individuals.
Retatrutide, a triple agonist targeting GIP, GLP-1, and glucagon receptors, significantly reduces bodyweight and improves glycemic control in adults with obesity and type 2 diabetes, showing promising efficacy and a manageable safety profil
A multisite randomized trial demonstrates that therapeutic horseback riding significantly reduces irritability and hyperactivity in youth with autism and psychiatric comorbidities, offering a valuable complementary intervention for behavior
A large single-center cohort study found no increased incidence of malignancy in patients with IgG4-related disease (IgG4-RD). Smoking and older age increased malignancy risk, while female sex and submandibular gland involvement were protec
Poor food access correlates with higher MASLD and frailty prevalence in liver transplant candidates, with geospatial clustering highlighting socioeconomic and environmental determinants impacting transplant candidacy and outcomes.
Alopecia areata regrowth may present atypically with acquired curly hair texture, associated with pili torti ultrastructural changes, signifying a unique phenotype requiring clinical recognition.
