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An integrated genomic and pharmacologic analysis identifies IMPDH2 as a key vulnerability in KRAS-mutant pancreatic cancer, showing that irreversible guanine nucleotide depletion potentiates KRAS-targeted therapies and offers a novel combin
This review synthesizes evidence on racial and ethnic differences in plasma phosphorylated tau 217 (%p-tau217) in preclinical Alzheimer disease, highlighting implications for diagnostic screening and biomarker validity across diverse popula
A large cohort study reveals that patients with mild autonomous cortisol secretion (MACS) in adrenal tumors are at increased risk for psychiatric disorders, highlighting the need for integrated psychiatric assessment in this population.
Prominent left atrial V waves in heart failure with preserved ejection fraction significantly increase right ventricular afterload independent of pulmonary vascular disease, challenging current hemodynamic assessments and impacting patient
This study reveals that various combinations of daily step counts and stepping intensity independently reduce all-cause and cardiovascular mortality, highlighting the importance of personalized physical activity strategies.
This study reveals that lower and declining social integration significantly increase long-term mortality risk after traumatic spinal cord injury, highlighting critical social determinants alongside clinical factors.
This study reveals that ameloblastomas uniquely maintain primary cilia and exhibit CEP164 overexpression, highlighting a distinct molecular signature that may influence tumor behavior and offer new diagnostic and therapeutic avenues.
Survodutide, a dual glucagon and GLP-1 receptor agonist, demonstrates significant weight loss and glycemic improvements in adults with obesity and type 2 diabetes, offering promise as a novel therapeutic agent with favorable efficacy and sa
This longitudinal study highlights how baseline Sense of Coherence and its changes over time impact health and functioning outcomes in rehabilitation patients, suggesting targeted interventions may improve recovery.
A multi-center RCT assessing the adjunctive use of the Paro-ComPas app in periodontal care found no significant overall benefit, though moderate app engagement showed potential for improved plaque control.
The ROAM/EORTC-1308 trial demonstrates that adjuvant radiotherapy after complete surgical resection of atypical meningioma significantly improves 5-year disease-free survival, reducing recurrence risk with manageable adverse effects.
A 34-day-old male infant with serum sodium >200 mmol/L from accidental salt ingestion was successfully treated with peritoneal dialysis, leading to full recovery.
A validated set of 17 quality indicators (QIs) for lupus nephritis, derived from the 2025 EULAR recommendations, shows variable adherence in practice and an association between higher adherence and lower damage accrual in a tertiary-care co
Baseline lung allograft dysfunction (BLAD) affects over 60% of bilateral lung transplant recipients, associates with increased mortality, and influences long-term lung function trajectories. Risk factors include higher BMI, prolonged ICU st
The phase 2 MIRA trial shows sonelokimab, an IL-17A/F-inhibiting nanobody, significantly improves outcomes in moderate-to-severe hidradenitis suppurativa with good tolerability compared to placebo.
A 19-year retrospective study demonstrates that the nasolabial muscle tension line reconstruction technique yields long-term aesthetic and functional improvements in microform cleft lip repair, with robust nasolabial symmetry and minimal sc
This study compares mood stabiliser monotherapy, second-generation antipsychotic monotherapy, and combination therapy for maintenance treatment after first psychotic manic episodes, showing mood stabilisers reduce relapse risk.
This study reveals how diabetes and ASCVD alter the link between soluble TNF receptor 1 levels and 90-day sepsis mortality, informing biomarker-guided risk assessment and understanding of sepsis pathobiology.
This case explores decision-making support for a man with autism spectrum disorder and prostate cancer, emphasizing tailored communication strategies in serious illness care.
This study provides a comprehensive single-cell immune atlas of multiple myeloma, revealing dynamic tumor microenvironment ecotypes linked to disease progression, immune dysfunction, and treatment response, offering new avenues for precisio
