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Tissue-informed circulating tumor DNA assays demonstrate high detection rates and exceptional sensitivity and specificity in monitoring HPV-positive and HPV-negative head and neck squamous cell carcinoma, supporting their clinical utility i
This study investigates the association between peri- and post-menopausal hormone replacement therapy (HRT) and the risk of voice disorders, revealing transiently increased dysphonia risk within the first nine months but no sustained clinic
A two-stage tracheal reconstruction approach in well-differentiated thyroid carcinoma with tracheal invasion shows high decannulation rates, functional recovery, and promising 3-year survival, supporting its use for extensive tracheal defec
A new living donor liver transplant program in the U.S. demonstrates that adult living donor hepatectomy can be safely implemented, with surgical proficiency and donor outcomes improving through accumulated experience.
This review summarizes the clinical characteristics, disease course, and survival outcomes of lung metastases after gastrectomy in gastric cancer patients, highlighting prognostic factors and the role of pulmonary metastasectomy.
A national survey reveals that most US surgeons report high workload hours and a majority perceive their workload as excessive, with factors such as years in practice, gender, and specialty influencing burden perception.
A multicenter study developed a robust exosomal microRNA-based model enabling preoperative detection of occult liver micrometastasis in pancreatic ductal adenocarcinoma, improving risk stratification and guiding treatment sequencing.
This study assesses the procedural maturation and midterm durability of the posterior rectus sheath flap (PoRSHA) for hiatal reinforcement in complex paraesophageal hernias, demonstrating favorable recurrence rates and low donor-site morbid
A Europe-wide prospective study shows wide variation in morphology-based surgery for chronic pancreatitis and no clear outcome advantage from current guideline concordance — underscoring the need for unified, clearer recommendations on rese
This article reviews a novel laparoscopic technique for rectal endometriosis involving mesentery preservation and nerve-sparing hand-sewn anastomosis, demonstrating feasibility and neurovascular protection compared to conventional stapled m
This study identifies short cervical length, early gestational age at intervention, and abnormal donor umbilical artery Doppler as significant preoperative predictors of six-month survival after fetoscopic laser ablation for twin-twin trans
Transcriptomic analysis reveals age-related differences in levator ani muscle recovery after vaginal delivery, highlighting molecular pathways potentially contributing to pelvic organ prolapse risk in older first-time mothers.
This study analyzes 720 genotyped uterine leiomyomas, revealing distinct clinical behaviors and treatment responses across molecular subtypes, with MRI aiding prognostic stratification to inform surgical and pharmacologic management.
A quality-improvement study found that implementing a high-dose oxytocin protocol during the third stage of labor significantly reduced postpartum hemorrhage rates, especially after vaginal births, suggesting potential for wider institution
This review examines the development, efficacy, and safety of combined oral contraceptives (COCs), highlighting the emergence of natural-estrogen-containing formulations and their role in optimizing contraceptive care.
Drug-Induced Liver Injury (DILI) remains a pivotal challenge in drug development, with evolving drug modalities and clinical trial designs prompting updated regulatory perspectives from FDA specialists.
This review examines the clinical relevance of a ≥30% decrease in VCTE-derived liver stiffness in predicting fibrosis regression in MASH, highlighting modest predictive accuracy and the need for improved biomarkers.
A nationwide cohort study reveals that in IBD patients, colorectal cancer risk increases notably with multiple affected relatives, challenging current guidelines prioritizing early-onset family history for surveillance.
TAPIS subgroup analysis reveals that ticagrelor-aspirin combined with thrombolysis may improve outcomes in moderate ischemic stroke patients with multiple acute infarcts, without increasing hemorrhage risk, suggesting infarct pattern as a p
Cilostazol promotes dural lymphatic remodeling and hematoma clearance post-ICH without increasing bleeding risk, representing a promising therapeutic strategy to improve neurological outcomes.
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