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Emerging evidence from prospective birth cohorts reveals a dose-dependent association between early respiratory infections and the risk of childhood atopic dermatitis, independent of genetic predisposition and antibiotic exposure.
Comprehensive pre- and early postoperative models predict acute kidney injury and need for renal replacement after lung transplantation, improving risk stratification and enabling targeted nephroprotection.
Autoimmune conditions in acute interstitial pneumonia (AIP) are associated with reduced 90-day mortality and better discharge outcomes, indicating distinct clinical trajectories and opportunities for tailored care.
A recent study demonstrates that defining COPD exacerbation risk by any moderate or severe event over two years improves prediction accuracy and clinical decision-making compared to the standard one-year criteria.
This article reviews the global clinical variation in surgical management of idiopathic subglottic stenosis, highlighting heterogeneity in techniques, treatment algorithms, and satisfaction levels among clinicians across 42 countries.
Cryotherapy in benign subglottic and tracheal stenosis shows comparable outcomes to standard endoscopic treatments, with subgroup evidence suggesting benefits of non-thermal cryotherapy. Prospective studies are warranted.
This study examines lung transplantation patterns, associated risk factors, and post-transplant survival among rheumatoid arthritis-related interstitial lung disease patients in Ontario, revealing key clinical insights under a universal hea
Deupirfenidone, a deuterated form of pirfenidone, demonstrated efficacy in slowing lung function decline in IPF patients, with a favorable safety profile in a phase 2b trial, offering promise for improved treatment outcomes.
Meconium aspiration syndrome (MAS) significantly increases the risk of preschool asthma and bronchiolitis by disrupting neonatal airway development, highlighting the need for early respiratory monitoring and intervention strategies.
A landmark randomized trial demonstrates that multilevel stepped reminders targeting both primary care physicians and patients markedly improve adherence to annual lung cancer screening, while health communication alone may be insufficient
A large UK cohort study reveals that beta-blockers reduce mortality in COPD patients with heart failure or ischemic heart disease, but concurrent long-acting beta-agonists may attenuate this benefit.
Extra-pulmonary tuberculosis survivors exhibit persistent lung function impairments and respiratory symptoms, highlighting the need for screening and management of post-TB lung disease beyond pulmonary TB cases.
Sotatercept improves exercise tolerance in pulmonary arterial hypertension through pulmonary vascular remodeling, systemic decongestion with hemoconcentration, improved right ventricular-pulmonary artery coupling, enhanced cardiac output re
This large-scale longitudinal study reveals that chronic cough is linked with widespread grey matter volume reductions and accelerated brain atrophy, highlighting potential neurostructural underpinnings of cough hypersensitivity.
The SwissLEGIO score refines Legionella prediction in community-acquired pneumonia, enhancing specificity while maintaining high sensitivity, thereby optimizing microbiological testing and improving clinical management.
This article examines interleukin-6 (IL-6) as a key mediator of therapeutic efficacy in acute lung injury and COVID-19, highlighting its role in modulating inflammation and survival outcomes across multiple clinical interventions.
In patients with OSA and elevated blood pressure, comorbid insomnia is linked to a significantly greater blood pressure reduction following short-term CPAP therapy, highlighting the clinical importance of addressing both sleep disorders.
This study uses single-cell RNA sequencing of bronchoalveolar lavage cells to reveal immune dysregulation in COPD, highlighting profibrotic macrophages and monocytes as key players in airway remodeling and gas exchange impairment.
A single moderate COPD exacerbation markedly increases future exacerbation risk and long-term mortality, justifying its reclassification as high risk per GOLD 2026 guidelines and supporting refined risk stratification for better clinical ma
The 2026 international report redefines acute exacerbation across fibrotic interstitial lung diseases, proposes a framework to separate AE from other acute respiratory worsenings, and sets priorities for diagnosis, treatment, trial design,
