Section
This article explores disease stability as a key treatment target in COPD, analyzing major phase 3 trials that show stability predicts reduced exacerbations and mortality, supporting its use to guide therapy.
Analysis of over 19,000 bronchiectasis patients across 30 countries reveals a graded risk increase for future exacerbations with each prior event, challenging the fixed threshold concept of frequent exacerbators and confirming consistency a
Combining left ventricular global longitudinal strain and right atrial reservoir strain greatly improves risk prediction and stratification in pulmonary arterial hypertension, outperforming conventional imaging and clinical models.
This article explores how PUS7-induced pseudouridylation of TGFBI mRNA promotes pulmonary hypertension via epigenetic regulation, revealing promising new therapeutic targets.
This study explores rehabilitation initiation, progression, and physical activity levels in adult ECMO patients, highlighting early active rehabilitation feasibility and varied activity trajectories based on clinical goals.
Elevated serum amyloid A correlates with rapidly progressive interstitial lung disease and mortality in dermatomyositis, with combined assessment alongside anti-MDA5 antibody improving risk stratification.
This multicenter study validates the Venous Excess Ultrasound Score (VExUS) as a highly accurate, noninvasive tool to predict right atrial pressure in patients evaluated for pulmonary hypertension, outperforming isolated echocardiographic m
The EVER trial examined if a structured early mobilization protocol improves functional outcomes in ventilated patients with sepsis or respiratory failure. Despite earlier and increased mobilization, no significant functional benefit was ob
This study reveals that acute hypoxemic respiratory failure (AHRF) affects half of ICU patients needing respiratory support, with severity linked to worse outcomes. Lung-protective ventilation is common, underscoring the need for standardiz
A randomized, double-blind, placebo-controlled trial demonstrates gabapentin’s significant efficacy and acceptable safety for treating cough in IPF, supporting its clinical use amid limited alternatives.
Echocardiography-derived right ventricular phenotypes improve prognostic accuracy beyond standard risk tools in pulmonary arterial hypertension patients at first follow-up, refining survival predictions and guiding management strategies.
This study reveals that pulmonary artery stiffness and right ventricular function parameters independently predict mortality better than pulmonary vascular resistance in mild pulmonary hypertension, supporting their role in early disease ri
An analysis of 2,556 thymic tumor cases highlights tumor size as a significant predictor of survival outcomes across thymoma, thymic carcinoma, and neuroendocrine thymic tumors.
Admission eosinopenia (≤10 cells/μL) in adults with community-acquired pneumonia is associated with higher ICU admission, mechanical ventilation rates, and longer hospital stays, suggesting its utility as a biomarker for hospital resource p
Physical activity counteracts adiposity-induced immune suppression in lung cancer and non-tumor lungs, restoring antitumor immunity and slowing tumor progression, with implications for lung cancer interception.
Long-term data from lung cancer screening reveal centrilobular emphysema progression strongly associates with coronary artery calcification worsening, highlighting systemic vascular implications of this emphysema subtype.
This study evaluates the independent association between incidental emphysema found on routine screening chest CT scans and all-cause mortality in a large Korean cohort, highlighting implications for risk stratification among ever-smokers.
This qualitative study reveals that patients undergoing pulmonary function tests face emotional and informational challenges. A co-developed educational pamphlet improves understanding and may reduce anxiety, highlighting the need for patie
A recent MAIC study comparing mepolizumab and dupilumab in eosinophilic COPD patients found no significant difference between the treatments in reducing exacerbations or improving quality of life.
This article explores hyperinflammatory and hypoinflammatory phenotypes in severe pneumonia, their clinical impact, and translational mouse models that inform precision therapeutic strategies.
