Highlights
Stepped multilevel reminders directed at both primary care physicians and patients significantly enhance adherence to annual lung cancer screening (LCS) by 27.7 percentage points.
Patient-directed health communication alone, including print and video messaging, did not improve and slightly reduced adherence, highlighting complexity in patient engagement strategies.
The stepped reminder intervention demonstrated greater efficacy among current tobacco users compared to former users, emphasizing targeted opportunities for high-risk subgroups.
Multilevel strategies leveraging electronic health record (EHR) infrastructure and coordinated care facilitate pragmatic implementation within primary care-led LCS programs.