Section
This study elucidates how KLF9 mediates intermittent hypoxia-induced MASLD by suppressing NR4A1 and p38 MAPK signaling, paving the way for targeted therapies in OSA-associated metabolic liver disease.
A two-day stay at 2500 m altitude increases right ventricular afterload and impairs ventricular-arterial coupling but maintains oxygen delivery in stable pulmonary vascular disease patients.
A novel risk score incorporating COPD and graded renal dysfunction improves prediction of one-year mortality post-TAVI, showing excellent internal validity but requiring external validation before clinical use.
The SUMMIT study reveals that respiratory symptoms are common among lung cancer screening participants and associated with increased lung cancer diagnosis risk within one year, challenging conventional asymptomatic screening definitions.
The SynAIRgy phase 3 trial demonstrated that the fixed-dose combination of aroxybutynin and atomoxetine (AD109) significantly reduces airway obstruction and improves oxygenation in obstructive sleep apnea patients unable to tolerate positiv
This review synthesizes current evidence on the modified sleep apnea severity index (mSASI) as a composite metric integrating clinical and sleep study factors to predict cardiovascular risk in CPAP-intolerant OSA patients undergoing surgery
A novel conversation aid was developed and refined iteratively with patients and physicians to support shared decision-making for low carbon footprint inhaler prescribing in asthma and COPD, balancing environmental impact with safety and pa
This study reveals that hypoxia in centrally located EGFR-mutant lung adenocarcinomas drives an alveolar lineage imbalance via the ZAKα-MAPK-c-Fos pathway, promoting early tumorigenesis. Therapeutic oxygenation can restore lineage balance a
Pregabalin, a neuromodulator, significantly improves symptoms in the majority of patients with chronic neurogenic cough, offering a well-tolerated treatment option irrespective of gender or gastrointestinal comorbidities.
Latent class analysis of 889 adult PAH-CHD patients identified unique phenogroups with distinct survival outcomes and treatment responses, offering refined risk stratification and guiding personalized therapy.
A 4D-CT study reveals early lung mechanics changes after PEEP reduction in ARDS, showing significant alveolar derecruitment and decreased over-inflation with minimal tidal recruitment increase, informing lung-protective ventilation strategi
Unclassified pulmonary hypertension often reflects early-stage HFpEF linked to left heart and metabolic dysfunction, identifiable via dynamic right heart catheterization and metabolomics.
A recent Chest study shows that PSG metrics vary unevenly across nights, and AHI scored with 4% desaturation is less stable than AHI 3%/arousal. Hypoxic burden was more reproducible and may better reflect true OSA severity.
A longitudinal blood gene-expression study in children found an early neutrophil-driven immune pattern at age 1, followed by a persistent eosinophilic signature from 4.5 to 10.5 years in those who later developed asthma.
This review synthesizes evidence on SIPE lateralization corresponding to dependent body position during combat sidestroke, highlighting moderate concordance between lung ultrasound and chest x-ray findings and implications for field diagnos
This article reviews mepolizumab efficacy in COPD patients with variable blood eosinophil counts, showing benefits even with intermittent eosinophilia, expanding treatable phenotypes beyond persistent elevation.
In two US cohorts, combining serum cancer biomarkers and Histoplasma antibodies with the Mayo model improved discrimination of benign versus malignant pulmonary nodules, especially in intermediate-risk cases.
A prospective study found that fully remote respiratory therapy in a donor care ICU was feasible, safe, and labor-saving, with minimal need for bedside support and favorable organ recovery outcomes.
A multicenter German study shows pulmonary endoscopy produces substantial waste, much of it in procedure rooms, and suggests reusable gowns, procedural bundling, and recycling as practical ways to lower environmental impact.
A multicenter study suggests that 1-year quantitative CT fibrosis progression in IPF, particularly a rise of about 4%, is clinically meaningful and prognostically informative for transplant-free survival.
