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Host blood transcriptomic signatures effectively monitor treatment response and predict recurrence and mortality in drug-susceptible pulmonary tuberculosis, meeting WHO benchmarks and enabling personalized therapy strategies.
This study evaluates respiratory support and mortality trends in Andes virus-induced hantavirus cardiopulmonary syndrome (HCPS) across Chile, highlighting increased mortality during the COVID-19 pandemic period and a high requirement for in
This study classifies preterm prelabor rupture of membranes (PROM) into four intra-amniotic types, detailing differences in gestational age distribution, microbial profiles, and neonatal outcomes, highlighting risks associated with infectio
Solid organ transplant recipients have increased risk of HPV-driven anal dysplasia and cancer due to unique immune alterations from immunosuppression. This article explores the transplant-specific immune dysfunction underlying persistent HP
A Danish multicentre trial demonstrates that individualized, clinically guided antibiotic treatment lasting around 3 days is as safe as the standard 5-7 days in late-preterm and term neonates with culture-negative early-onset sepsis, signif
Late-onset sepsis (LOS) incidence among very preterm infants declined from 2010 to 2017 but has risen since, driven mainly by increasing infections from non-CoNS gram-positive bacteria and gram-negative pathogens, notably Staphylococcus aur
Solid organ transplant recipients exhibit heightened risk for HPV-associated anal dysplasia and cancer due to unique immunosuppressive alterations. A transplant-tailored model of mucosal immune dysfunction elucidates mechanisms driving pers
This study analyzes healthcare usage up to 12 months after COVID-19 infection, revealing prolonged increased utilization—especially among hospitalized patients—highlighting ongoing care needs for survivors.
Health authorities in New York State have confirmed the region’s first case of Bourbon virus , a rare and potentially deadly tick-borne infection for
This study evaluates the impact of Long COVID on pregnancy outcomes, finding no significant risk for preterm birth but a potential association with hypertensive disorders, underscoring the need for further research.
This study elucidates distinct temporal patterns of posterior segment imaging features in ocular syphilis correlated with symptom duration and laboratory markers, enhancing diagnostic timing and clinical interpretation.
Following pivotal trial data demonstrating reduced infection and pancreatic fistula rates with piperacillin-tazobactam prophylaxis in pancreatoduodenectomy, adoption of broad-spectrum antibiotics increased significantly, particularly among
A 7-day perioperative sofosbuvir/velpatasvir prophylaxis in HCV-positive donor to HCV-negative recipient kidney transplants demonstrated sustained virologic response in over 92% of cases, with favorable 1-year graft survival and function.
A pooled analysis from 22 countries demonstrates that rotavirus vaccination is highly effective in preventing rotavirus-positive acute gastroenteritis deaths in children under five, underscoring the vaccine’s critical role in reducing
A 2-week-old neonate developed congenital tuberculosis despite an asymptomatic mother, illustrating diagnostic challenges and the need for heightened awareness of TB in pregnancy.
This longitudinal study characterizes symptom variability and outcomes of respiratory infections among young children, revealing age-specific severity patterns and notable differences between influenza A and B.
AHB-137, an antisense oligonucleotide targeting HBV mRNA, demonstrated safety, favorable pharmacokinetics, and rapid HBsAg reduction in healthy volunteers and chronic hepatitis B patients, supporting further clinical development.
This analysis of the ZEDS trial suggests that valacyclovir prophylaxis offers temporally localized protection against recurrent ocular inflammation in herpes zoster ophthalmicus, supporting one-year suppressive therapy despite non-significa
Extra-pulmonary tuberculosis survivors exhibit persistent lung function impairments and respiratory symptoms, highlighting the need for screening and management of post-TB lung disease beyond pulmonary TB cases.
A pioneering study shows that AI-enhanced ECG screening combined with epidemiological data can identify undiagnosed Chagas disease cases, improving early detection and care in endemic Brazil.
