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A pioneering study shows that AI-enhanced ECG screening combined with epidemiological data can identify undiagnosed Chagas disease cases, improving early detection and care in endemic Brazil.
This review synthesizes evidence on the comprehensive economic impact of the 2025 New Mexico measles outbreak, emphasizing the high societal costs and critical role of vaccination-related public health interventions in outbreak control and
A multicenter prospective real-world study in China evaluated treatment outcomes of tinea capitis, highlighting itraconazole’s superior efficacy over terbinafine for certain fungal strains like Microsporum canis, informing optimized a
The SwissLEGIO score refines Legionella prediction in community-acquired pneumonia, enhancing specificity while maintaining high sensitivity, thereby optimizing microbiological testing and improving clinical management.
Adjuvant pegylated interferon following nucleos(t)ide analogue withdrawal in HBeAg-negative chronic hepatitis B significantly increases HBsAg loss rates and reduces severe hepatic flares over three years compared to withdrawal alone.
The AFRI-c trial found no significant reduction in respiratory infection rates or staff absenteeism in care homes using HEPA filters during winter, highlighting the need to maintain established infection control measures.
This article reviews the accelerated evidence generation for anticoagulation in noncritically ill COVID-19 patients, highlighting how coordinated trials and data sharing influenced clinical guidelines and patient outcomes during the pandemi
Six cases of postoperative fungal endophthalmitis caused by Sarocladium kiliense following cataract surgery involving contaminated trypan blue are reported, highlighting diagnosis, management, and outcomes.
Persistent tissue hypoperfusion alongside vasopressor dosing improves early risk stratification in refractory septic shock, identifying patients with markedly increased 28-day mortality beyond vasopressor dose alone, as shown in a secondary
The GAPS protocol significantly reduced surgical-site infections in implant-based breast reconstruction over five years, suggesting structured perioperative infection control enhances patient outcomes and healthcare efficiency.
Early administration of Shenfu injection in septic ICU patients did not reduce vasopressor use but was associated with lower mortality and improved microcirculation, warranting further validation.
Emergency departments serve as vital venues for hepatitis C virus screening, particularly for persons experiencing homelessness who exhibit higher HCV prevalence and face healthcare access barriers. Evidence supports nontargeted screening i
This article explores recent outbreaks of Cyclospora and Cryptosporidium infections in the U.S., their transmission, clinical features, diagnosis, treatment, and prevention, highlighting the public health impact and clinical challenges.
A comprehensive single-cell atlas of lung immune cells reveals distinct immune responses in mild versus severe influenza, highlighting neutrophil dysfunction and lymphocyte impairment as key drivers of pathology.
The APS Consortium establishes a large, prospective cohort of critically ill adults with ARDS, pneumonia, and sepsis to enable biologically based phenotyping, leveraging rich clinical data and biospecimens for improved understanding and the
Pregnant and postpartum individuals continue to face higher risks of severe COVID-19 outcomes, including hospitalization and pneumonia, even after the pandemic emergency has ended, emphasizing the need for ongoing vigilance and tailored cli
This article explores the mechanism by which HBV induces liver fibrosis through pyruvate-dependent ROS production and PPARα inhibition, highlighting novel therapeutic targets for chronic hepatitis B management.
A cluster randomized trial in Toronto nursing homes found that on-site multiplex PCR testing improved viral detection and reduced emergency department transfers during respiratory outbreaks, though it did not alter outbreak size or frequenc
This study characterizes neurological complications in adult Ebola survivors over 7 years, demonstrating persistent cognitive and neuropsychiatric deficits despite gradual improvement, underscoring the need for ongoing neurological follow-u
This article reviews updated clinical understanding of Ebola virus disease in pregnancy amid the Democratic Republic of Congo outbreak, highlighting maternal outcomes, risks of vertical transmission, treatment challenges, and the critical n
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