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White blood cell count modifies mortality outcomes in sepsis patients treated with cefepime versus piperacillin-tazobactam, suggesting its potential role in guiding antibiotic selection.
An 8-week course of bemnifosbuvir and ruzasvir showed high sustained virologic response rates with excellent safety in treatment-naïve chronic hepatitis C patients across genotypes, including those with baseline resistance mutations.
This multicentre Italian study comparing clarithromycin and azithromycin for hospitalized infants with pertussis shows clarithromycin is linked to better clinical outcomes, including lower severity and fewer ICU admissions.
This phase 3 trial demonstrates that clesrovimab, a long-acting monoclonal antibody, is safe and well-tolerated in infants at risk for severe RSV disease across two consecutive RSV seasons, supporting its role in extended RSV prophylaxis.
This study elucidates the distinct clinical, pathological, and prognostic differences between native and allograft BK polyomavirus nephropathy, highlighting the severity and poorer outcomes associated with native-kidney BKPyVN and stressing
This study validates temperature-trajectory sepsis subphenotypes in a large Chinese ICU cohort, linking immune and coagulation dysfunction with mortality and highlighting differential responses to immunoglobulin therapy, particularly benefi
This multicenter study of 305 eyes over 12 years reveals pathogen-specific clinical features and outcomes in culture-positive endogenous endophthalmitis, highlighting unique presentations, prognosis, and risks especially for gram-negative a
This comprehensive 10-year ICU study reveals a low prevalence of positive pleural fluid cultures, highlights the significant link to suspected pleural infection, and associates culture positivity with higher 90-day mortality, informing targ
This study explores how patient language preference affects the offer and acceptance of hepatitis C screening in emergency departments, highlighting disparities and suggesting targeted approaches to improve screening among non-English speak
Monitoring chronic pulmonary aspergillosis progression using time-normalized anti-Aspergillus IgG kinetics shows promise for early detection of disease worsening, supporting timely clinical reassessment alongside imaging and microbiology.
This analysis of U.S. CF Foundation registry data reveals that inhaled antibiotics confer lung function benefits primarily in chronic Pseudomonas aeruginosa infections, but their treatment benefit has declined with CFTR modulator use. Risks
This review synthesizes evidence on persistent excess mortality after SARS-CoV-2 infection in people with severe mental illness (SMI) during and following COVID-19 vaccination roll-out in England, highlighting disparities in mortality risk
This nationwide Swedish study tracks shifting predictors of critical illness during different COVID-19 pandemic periods and compares them to seasonal influenza, highlighting vaccination status and age as key risk factors for severe outcomes
This study elucidates the incidence and characteristics of respiratory viral infections (RVIs) within 100 days following hematopoietic cell transplant and CAR T-cell therapy, highlighting SARS-CoV-2 as the predominant pathogen and identifyi
The RADICAL consortium’s large-scale study reveals a high long-term transition rate from immune tolerant to immune active chronic hepatitis B, especially in patients with high-normal ALT, suggesting the need for closer monitoring and
A large multicenter study shows that balanced crystalloids administered before ICU admission in sepsis patients reduce 30-day mortality compared to saline, supporting early fluid choice’s impact on sepsis outcomes.
This article reviews recent evidence on how HBV manipulates monocyte-to-macrophage differentiation through metabolic and epigenetic reprogramming, facilitating immunosuppression and chronic infection.
The ST120 strain of Mycobacterium massiliense, prevalent in East Asia, exhibits unique genetic features linked to increased virulence and worse treatment outcomes in pulmonary disease.
This study elucidates how intestinal blood vessel-associated macrophage dysfunction contributes to gut-vascular barrier breakdown and bacterial translocation in cirrhosis, revealing novel mechanisms that underlie systemic infection risks in
Distinct Pseudomonas aeruginosa abundance and interaction patterns in bronchiectasis patients reveal heterogeneity influencing clinical outcomes and treatment responses, offering new avenues for personalized management.
