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This review evaluates how deep learning-assisted delta radiomics on MRI, combined with AFP response, provides a non-invasive, high-accuracy prediction of pathological complete response in unresectable HCC undergoing conversion immunotherapy
This review details a breakthrough in esophageal adenocarcinoma treatment, identifying the APE1-SOX9 axis as a primary driver of chemoresistance and demonstrating how targeting APE1’s redox function can sensitize tumors to oxaliplatin
This review synthesizes findings on how periventricular white matter hyperintensities (PWMHs) drive cognitive impairment in Aβ-negative individuals through distinct metabolic mediation and direct structural pathways, highlighting the clinic
This post hoc analysis of the CREDENCE trial reveals that low-normal sodium intake increases cardiovascular risk in T2D and CKD, a risk significantly mitigated by canagliflozin, while renal protection remains consistent across sodium intake
This review analyzes multinational data showing a significant decline in cardiovascular mortality among diabetes patients, alongside a concerning rise in dementia-related deaths and the emergence of cancer as a leading cause of mortality in
This review analyzes the real-world one-year outcomes and healthcare costs for HFrEF patients on quadruple therapy, revealing significant residual risk despite optimized pharmacologic management.
This review explores how adipocyte-derived small extracellular vesicles (sEVs) use surface-bound adiponectin to protect the heart, and how diabetes-induced GRK2 upregulation disrupts this vital signaling pathway, leading to ischemic heart f
A large-scale cohort study reveals that solid organ transplant recipients with pre-existing cancer histories face significantly elevated risks for subsequent malignancies, particularly recurring or de novo cancers of the same type, necessit
This review synthesizes evidence comparing SGLT2 inhibitors and GLP-1 receptor agonists, highlighting a significant reduction in chronic kidney disease and acute kidney injury risks associated with SGLT2i initiation.
This review evaluates a novel open-source extraction pipeline designed to standardize and automate the processing of complex HSCT registry data, enhancing reproducibility and precision in clinical outcomes research.
A landmark study identifies a decade-long conserved sequence of disease progression in IPF, revealing that DLCO decline precedes FVC impairment by years, providing a new framework for early diagnosis and clinical trial design.
Recent data from the NIH All of Us Research Program indicates that Fuchs’ Endothelial Corneal Dystrophy (FECD) is associated with a significantly higher prevalence of cardiometabolic comorbidities, suggesting a systemic component to t
This review analyzes the high prevalence of anxiety and depression in patients with Retrograde Cricopharyngeus Dysfunction (RCPD) and evaluates the significant, sustained mental health improvements following cricopharyngeal botulinum toxin
A large-scale cohort study of premenopausal women demonstrates that adjuvant tamoxifen significantly increases the risk of endometrial cancer, hyperplasia, and polyps, with risk correlating to treatment duration.
A comprehensive review of a multicenter RCT (Morone et al., 2026) demonstrating that exoskeleton-based robot-assisted therapy significantly improves upper limb motor impairment and clinical outcomes in the early subacute phase of stroke rec
This review synthesizes recent evidence on the role of pretreatment virus-specific T cells in predicting clinical response, survival, and safety outcomes in patients with progressive multifocal leukoencephalopathy (PML) treated with immune
A randomized cross-over trial reveals that empagliflozin enhances beta cell function and insulin sensitivity more effectively than titrated insulin, suggesting benefits beyond simple glucotoxicity relief.
This review analyzes the lifestyle patterns of pregnant women with type 1 diabetes, synthesizing findings from the ENDIA study with recent evidence on nutritional adequacy, islet autoimmunity, and the molecular mechanisms of metabolic compe
This review analyzes the ICSM Phase III study, highlighting how a structured empowerment program and standardized protocols in EMS significantly reduced prehospital delays and tripled alteplase administration rates for acute ischemic stroke
This review analyzes the significant long-term thyroid toxicity burden in high-risk neuroblastoma survivors, identifying key risk factors such as molecular radiotherapy, tandem myeloablative therapy, and immunotherapy.
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