Section
This study explores diverse stakeholder views on oral health needs and care for dependent older adults, highlighting the importance of subjective outcomes like comfort and function often overlooked in service provision and research.
This phase 3 trial shows that tarlatamab combined with durvalumab significantly improves overall and progression-free survival compared to durvalumab alone as maintenance therapy post-first-line chemoimmunotherapy in extensive-stage small-c
Regular exercise in midlife women moderates age-related cognitive decline, particularly in processing speed and demanding working memory tasks, with resistance training showing unique benefits for reaction time.
This qualitative study reveals empowerment as central to promoting safer mobility in Parkinson’s disease, emphasizing individualized, contextual, and collaborative strategies for fall prevention.
Eating difficulty is associated with broader functional vulnerability and cognitive decline, rather than directly triggering dementia, highlighting its importance in comprehensive geriatric assessment beyond dental health screening.
The PANKU-Lung01 phase 3 trial demonstrates izalontamab brengitecan significantly extends progression-free survival compared to platinum-based chemotherapy in EGFR-mutated advanced non-squamous NSCLC after failure of third-generation EGFR T
This study tracks executive function trajectories from age 2 to 13 in very preterm children, revealing enduring difficulties compared to full-term peers and highlighting the need for early and ongoing interventions, particularly accounting
This study identifies a CCL20+ macrophage subpopulation as a major source of TNF in axial spondyloarthritis synovium, driven by CD40L and an IL-1β/TNF-α autocrine loop, providing insights into disease pathogenesis and therapeutic targets.
Combining serum leucine-rich alpha-2-glycoprotein 1 (LRG-1) with citrulline offers a sensitive, noninvasive biomarker strategy for early detection and monitoring of rejection in intestinal transplantation, potentially reducing reliance on i
This retrospective study evaluates the incidence and risk factors for infantile hemangioma ulceration following oral propranolol therapy, highlighting subtype-related risks and anatomical protective factors to guide clinical management.
In a randomized trial, sodium citrate as an anticoagulant in concentrated growth factor therapy for androgenetic alopecia reduced injection pain, improved hair density, and increased patient satisfaction compared with heparin sodium or no a
Sepsis triggers mitochondrial impairment in platelets, promoting hyperactivation via ROS production. The mitochondria-specific antioxidant MitoTEMPO reverses these changes in vitro, suggesting therapeutic potential to prevent sepsis-related
Cardiovascular risk prediction models show limited accuracy in postmenopausal women with chronic kidney disease, often underestimating risk, highlighting the need for improved tools in this high-risk population.
This nationwide study reveals that donor cell-derived hematologic neoplasms (DDHN) after allogeneic stem cell transplantation are rare but linked mainly to inherited germline mutations in related donors, underscoring the need for comprehens
This article explores the role of the macrophage YTHDC1/TIGAR/NF-κB axis in pulmonary hypertension and highlights its potential as a therapeutic target to mitigate inflammation-driven vascular remodeling.
The University of California, Irvine Corneal Cystine Crystal Score (UCI CCCS) is validated as a reliable slit-lamp grading tool correlating with corneal densitometry and symptoms in cystinosis, though not visual acuity, highlighting its val
This study reveals that psychosocial stress induces vocal fold epithelial barrier dysfunction irrespective of microbiota presence, while microbiota presence uniquely promotes stress-induced epithelial proliferation in vocal folds, suggestin
The STOPS trial demonstrates noninferiority of subtotal colectomy with cecorectal anastomosis compared to total colectomy with ileorectal anastomosis for refractory slow-transit constipation at 1 year, balancing symptom relief with postoper
A randomized trial shows that intraoperative Lugol’s iodine staining during LEEP increases positive resection margins and should not be routinely applied, despite reducing postoperative bleeding duration.
The PIONIR randomized crossover trial demonstrates that a specific Tasty&Healthy diet significantly reduces fecal calprotectin levels, a marker of gut inflammation, in first-degree relatives at high risk for Crohn’s disease, sugge
