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Routine DAT offers limited additional clinical value over transcutaneous bilirubin monitoring in low-risk ABO and RhD-incompatible neonates, supporting guideline shifts towards selective DAT use and emphasizing maternal antibody screening.
Brepocitinib, a selective TYK2-JAK1 inhibitor, showed rapid, sustained skin disease control, itch relief, and improved quality of life in dermatomyositis patients over 52 weeks with an acceptable safety profile in a global phase 3 trial.
Few US adults with alcohol or opioid use disorder reported addiction pharmacotherapy use in 2022-2023. Pharmacotherapy receipt was linked to increased healthcare utilization, underscoring the need for early outpatient intervention strategie
Mezigdomide targets IKZF1/IKZF3 to reverse T-cell exhaustion, enhancing cytokine production and improving T-cell engager efficacy in multiple myeloma, a breakthrough in overcoming immunotherapy resistance.
The ODDESSI trial evaluated Open Dialogue versus treatment as usual in adults presenting in mental health crisis, finding no reduction in relapse time but improved service outcomes and reduced inpatient admissions with Open Dialogue.
GLP-1 receptor agonists reduce mortality and cardiovascular events more effectively than SGLT2 inhibitors in serious mental illness (SMI), with early benefits and consistent effects across bipolar disorder, major depression, and schizophren
A randomized, double-blind, placebo-controlled trial demonstrates gabapentin’s significant efficacy and acceptable safety for treating cough in IPF, supporting its clinical use amid limited alternatives.
Neighborhood deprivation measured by ADI correlates with poorer pre-implant speech recognition and quality of life but does not impact post-implantation benefits, highlighting socioeconomic disparities in cochlear implant access rather than
Healthcare professionals face significant gaps in cardiovascular prevention despite their critical role in care. The ESC Congress 2025 revealed prevalent modifiable risks, underuse of therapies, and subclinical atherosclerosis, underscoring
The NOTION-4 trial demonstrates that 3 months of DOAC therapy post-TAVR reduces early HALT incidence compared to SAPT, but benefits diminish after discontinuation, highlighting nuanced balance between thrombosis prevention and bleeding risk
Universal dispensation of aspirin at 162 mg daily in high-risk pregnant populations reduces preeclampsia with severe features without increasing adverse maternal or neonatal outcomes, supporting broad aspirin use beyond risk-based prescribi
Virtual reality-based digital defocus vision training (DDVT) shows promise as a home-based adjunct to slow myopia progression in children, with randomized trial data demonstrating modest reductions in axial length and refractive error progr
Norwegian cohort data reveal no protective effect of rotavirus vaccination against type 1 diabetes onset in early childhood, clarifying prior conflicting findings.
This review synthesizes current evidence on hemoglobin thresholds in heart failure, highlighting that optimal prognosis is associated with hemoglobin levels higher than WHO anemia cutoffs, with clinical implications for management and iron
This review synthesizes current evidence on myocardial fibrosis and ventricular remodeling after AVR in chronic AR, highlighting imaging biomarkers, remodeling patterns, and functional outcomes relevant to clinical practice.
This review synthesizes evidence on the prevalence and prognostic value of right ventricular dysfunction in ATTR-CM and the therapeutic impact of vutrisiran on RV function from the HELIOS-B trial, underscoring RV free wall strain as a key b
The TRANSPORT trial showed no superiority of liberal versus restrictive RBC transfusion in septic shock patients with cancer, highlighting no mortality benefit and increased thrombotic events with liberal strategy, underscoring the need for
This review synthesizes a meta-analysis of relapse trajectories following paliperidone discontinuation with evidence on antipsychotic maintenance and discontinuation strategies, highlighting individualized risk stratification and clinical i
Technology-guided diet counseling training using the Nutri platform improves resident physicians’ attitudes, self-efficacy, and intention to discuss diet, facilitating shared decision making in routine primary care.
This review examines emerging evidence on AI-assisted LC-OCT as a noninvasive, accurate tool for detecting subclinical basal cell carcinoma in high-risk patients, highlighting diagnostic performance, subtype classification, and translationa
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