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11-oxygenated androgens, notably 11β-hydroxytestosterone and 11-ketotestosterone, are elevated in women with polycystic ovary syndrome (PCOS) in a phenotype-dependent manner. Oral contraceptive pills (OCPs) markedly suppress these adrenal-derived androgens, whereas metformin induces modest reductions, and lifestyle modification shows no significant short-term effect. These findings support the potential of 11-oxygenated androgen profiling in refining PCOS diagnosis and monitoring therapeutic responses.
