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Melatonin impairs glucose tolerance and early insulin secretion, particularly in carriers of the MTNR1B diabetes risk allele, revealing critical mechanisms linking melatonin signaling to diabetes susceptibility and highlighting the need for
A large study in veterans with type 2 diabetes found that adding GLP-1 receptor agonists to basal insulin did not improve insulin discontinuation rates compared to SGLT-2 inhibitors or DPP-4 inhibitors over three years.
This article examines factors influencing the one-year success rate of DMEK in treating corneal endothelial dysfunction, highlighting the impact of operative complications and donor-recipient variables based on findings from the Diabetes En
A large-scale proteomic study identified distinct MASLD subtypes influenced by sex differences and developed a four-protein score predicting all-cause mortality, advancing personalized risk assessment beyond traditional liver-centric models
This retrospective study assesses the efficacy and safety of pemetrexed, alone or combined with carboplatin, as salvage therapy for advanced thyroid cancer, showing promising response rates comparable to current second-line treatments.
This study demonstrates that dapagliflozin does not impair LDL catabolism but favorably shifts VLDL1 and VLDL2 catabolism toward normal physiology in type 2 diabetes, potentially contributing to reduced atherosclerosis risk.
A 2022 nationwide study shows insulin pump therapy in adults with type 1 diabetes is associated with significantly lower 30-day readmissions and reduced in-hospital mortality compared to injectable insulin alone.
Common bedside tests for peripheral arterial disease in diabetic patients show poor sensitivity, challenging their clinical reliability compared to advanced imaging modalities.
A nationwide cohort study found that SGLT2 inhibitor initiation was associated with a 27% lower risk of incident lung cancer in patients with COPD and type 2 diabetes compared with sulfonylureas.
A randomized trial found that levothyroxine treatment for subclinical hypothyroidism or hypothyroxinemia starting between 8 and 20 weeks of gestation did not improve IQ scores in children at age 5 years compared with placebo.
Long-term exposure to particulate matter and lack of green space were associated with increased risk of prediabetes, especially impaired glucose tolerance phenotypes, and reduced remission of isolated impaired fasting glucose.
In a prospective cohort study using multiple 24-hour urine collections, higher sodium excretion was associated with a 32% increased type 2 diabetes risk per 1,000 mg/day; potassium excretion showed no significant association.
A meta-analysis of 23 observational studies shows higher MIND diet adherence is associated with a 55% lower cancer risk and reduced all-cause and CVD mortality. Separately, the MIND trial now provides genetic data to explore precision nutrition for cognitive decline.
A metabolomic clock based on plasma metabolites accurately estimated chronological age (r=0.92) and was associated with mortality, frailty, and cognitive impairment across two European cohorts.
A cohort of 432 children with Graves disease found 24% developed neutropenia on methimazole, mostly within the first month. TPOAb-negative status and younger age increased risk.
A liver fibrosis risk score (pFIB-6) identifies children with obesity at markedly increased short-term risk of type 2 diabetes, offering a potential tool for early risk stratification.
Severe hypertriglyceridemia (TG >500 mg/dL) affects ~1 in 88 adults and carries risks of pancreatitis and cardiovascular disease. Novel therapies targeting apoC-III, notably plozasiran siRNA, demonstrate dramatic TG reductions and pancreatitis risk mitigation. Pediatric management remains guideline-limited. Standardization of definitions is needed.
This study examines how gestational diabetes and BMI changes between pregnancies impact hospital stay length and birthing costs, highlighting the importance of preventive care.
A propensity-weighted analysis suggests that shorter antithyroid drug therapy (<12 months) in Graves' disease patients with low baseline TRAb is broadly comparable to the standard 12-18 months in preventing relapse, supporting indiv
Acute mild cold exposure with shivering significantly reduces 24-hour glucose levels and improves glycemic profiles in individuals with type 2 diabetes, but not in prediabetic subjects, suggesting a potential non-pharmacological interventio
