Proteomic Insights into MASLD: Sex-Specific Endotypes and Predictive Value for Mortality
Highlight
- Latent class analysis of over 48,000 UK Biobank participants with MRI-defined hepatic steatosis reveals distinct MASLD clinical subtypes with strong sex-based differences.
- A novel four-protein biomarker panel (PS4), linked to lipid metabolism and immune pathways, predicts all-cause mortality more accurately than existing non-invasive scores.
- Proteomic components mediate 10-20% of the mortality risk attributable to MASLD phenotypic classes, highlighting key biological pathways driving systemic outcomes.
Study Background
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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.