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COMBINE 4 demonstrated that once-weekly IcoSema (icodec+semaglutide) offers superior glycemic control, weight reduction, and reduced hypoglycemia versus daily insulin glargine U100 in insulin-naive type 2 diabetes patients, supported by com
This review integrates recent randomized trial data with observational studies to clarify cannabis inhalation’s acute impact on cardiac ectopy, physical activity, sleep, and glucose, highlighting complex arrhythmia associations and cl
This study reveals a significant early onset of metabolic syndrome in men with prostate cancer treated with combined ADT and ARPI therapies, highlighting the necessity for multidisciplinary metabolic monitoring and interventions.
We report five pediatric MEN2B cases highlighting early extra-endocrine signs such as persistent constipation and alacrimia, enabling prompt genetic diagnosis and thyroidectomy before medullary thyroid carcinoma progression.
This study investigates how semaglutide exposure before and during pregnancy affects gestational weight gain and key pregnancy outcomes in women with overweight or obesity, highlighting increased risks that may stem from treatment discontin
A new sonographic pattern characterized by discontinuous peripheral punctate echogenic foci (DPEF) in thyroid nodules is strongly associated with papillary thyroid carcinoma (PTC), suggesting its potential as an important diagnostic marker
This study reveals a high heart failure risk within 5 years of diabetes diagnosis, highlighting insulin resistance and reduced kidney function as independent predictors beyond conventional risk factors.
A phase II basket trial demonstrates that vosoritide significantly increases growth velocity in children with RASopathies, ACAN, and NPR2 deficiencies, with an acceptable short-term safety profile, suggesting its potential as a precision th
This study reveals significant HbA1c and glucose discrepancies, especially in Black individuals, and introduces a personalized HbA1c correction (pA1C) that enhances diabetes management across racial groups.
A novel enzymatic assay measuring fasting 2-hydroxybutyrate shows high accuracy in identifying postprandial dysglycemia in individuals with normal fasting glucose and HbA1c, offering an improved screening approach for early glucose metaboli
Normothermic regional perfusion (NRP) offers a promising approach to reduce ischemic injury in pancreas and islet transplantation using donation after circulatory death (DCD) donors, improving graft quality and expanding donor availability.
A novel longitudinal obesity medicine training pathway for internal medicine residents, implemented at an urban Federally Qualified Health Center, improves physician confidence and management skills in obesity care, preparing trainees for b
This study examines how bariatric surgery and gestational diabetes mellitus independently and jointly impact maternal and neonatal outcomes, highlighting increased risks and the need for personalized antenatal care.
The TC-MAX is the first validated, disease-specific instrument measuring thyroid cancer-related anxiety, showing strong reliability and validity to inform treatment decisions and improve patient-centered care.
Concurrent exercise added to a palaeolithic diet improves cardiometabolic fitness and post-exercise clearance of ceramides, enhancing fat oxidation in individuals with type 2 diabetes.
Cirrhosis entwined with diabetes presents unique clinical challenges. This article offers a pragmatic framework for diagnosis, tailored therapies, and multidisciplinary care to enhance outcomes across liver disease stages.
This study evaluates four commercially available AI systems for diabetic retinopathy screening in Tanzania, demonstrating high sensitivity for referable and proliferative DR and highlighting considerations for implementation in low-resource
End-stage metabolic dysfunction-associated steatohepatitis (MASH) features profound disruptions in thyroid hormone metabolism across liver, portal, and systemic compartments, with the hepatic T3 level and systemic T3/rT3 ratio serving as se
A significant subset of type 1 diabetes patients exhibit low faecal elastase indicative of exocrine pancreatic insufficiency (EPI), associated with longer diabetes duration but not with major changes in diet or symptoms, highlighting the ne
Temple syndrome is an under-recognised imprinting disorder with complex endocrine and growth abnormalities. This large-cohort study clarifies its phenotype, highlights growth hormone therapy benefits, and proposes a novel clinical scoring s
