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This study examines how temporal cortisol secretion changes in benign adrenal incidentalomas relate to long-term cardiometabolic outcomes and mortality, highlighting the significance of persistent mild autonomous cortisol secretion for hype
Prolonged mild sleep restriction of 1.5 hours per night over six weeks leads to modest weight gain, increased adiposity, and elevated leptin levels, highlighting the importance of adequate sleep in weight management and cardiometabolic risk
This case series reveals a high prevalence of uncontrolled hypertension among diabetic patients visiting ophthalmology clinics and highlights the importance of in-clinic blood pressure screening to identify and manage cardiovascular risk.
Reviewing ADA 2022 vs ACOG criteria and timing effects on postpartum OGTT in GDM women reveals inpatient testing increases screening uptake but varies in diabetes classification; highlights the need for consensus on test timing and interpre
This analysis reviews a pilot study evaluating high-dose levothyroxine treatment in adult RTHα patients, demonstrating safety, improved quality of life, and distinct metabolic alterations over three years.
This study reveals that endogenous glucose-dependent insulinotropic polypeptide (GIP) significantly enhances postprandial splanchnic blood flow in people with type 2 diabetes, influencing insulin secretion without affecting glucose levels.
Recent evidence indicates that advances in imaging and hormonal testing allow a reduction in the use of bilateral inferior petrosal sinus sampling without compromising diagnostic accuracy in Cushing’s disease.
The PRISM trial evaluated a precision medicine program using biogenetic markers and multidisciplinary care in Chinese young-onset diabetes patients, improving metabolic control and patient well-being but not reducing complications over thre
The HumAn-1 trial found no significant differences between insulin glargine and human isophane insulin in hypoglycemia risk or glucose control in young T1D patients in low-resource settings, underscoring accessibility over insulin type in t
A NIDDK workshop highlighted the crucial role of real-world evidence in addressing gaps about GLP-1 receptor agonists’ safety, effectiveness, adherence, and economic impact to improve clinical and regulatory decision-making.
Researchers developed and validated the FMO score, a noninvasive, cost-effective tool to identify at-risk metabolic dysfunction-associated steatohepatitis (MASH) in obese patients, showing strong predictive performance across multiple inter
This study examines how obesity and alcohol consumption jointly impact diabetes risk over time in an Asian cohort, highlighting differences in interaction measures and implications for diabetes prevention.
This study of 800 men with infertility demonstrates that a detailed pathophysiology-based classification reduces idiopathic cases and identifies distinct endocrine profiles, enabling targeted management.
A population-based study reveals a significant reduction in impaired awareness of hypoglycemia and severe hypoglycemia in youth with type 1 diabetes from 2002 to 2024, indicating substantial progress in diabetes care and the ongoing need fo
The Global-MASLD study identifies key predictors of advanced fibrosis and mortality in metabolic dysfunction-associated steatotic liver disease, highlighting the prognostic value of noninvasive fibrosis markers across diverse populations.
This real-world study demonstrates a dose-dependent increase in suboptimal thyroid hormone control among adults treated with levothyroxine, emphasizing the need for enhanced TSH monitoring in patients on higher doses.
This review synthesizes evidence linking the 2025 Primary Aldosteronism Severity Classification (PASC) with adrenal venous sampling (AVS) lateralization and treatment outcomes, highlighting its potential to enhance precision in PA managemen
A 12-week randomized trial explored sleep optimization in adults with type 1 diabetes, revealing improved sleep quality and reduced diabetes distress but limited glycemic benefits except in patients with baseline A1C ≥7%.
The TUXEDO-2 trial demonstrated that ultra-thin strut biodegradable polymer sirolimus-eluting stents are noninferior to durable polymer everolimus-eluting stents in diabetic patients with multivessel coronary artery disease at 1-year follow
Iterative redesign of electronic health record (EHR) portal reminders significantly improved mammography screening adherence in an outpatient setting, demonstrating the value of concise messages with scheduling links, while retinal and HbA1
