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A prospective study found that fully remote respiratory therapy in a donor care ICU was feasible, safe, and labor-saving, with minimal need for bedside support and favorable organ recovery outcomes.
MICROINHALO found that automatic cuff pressure control plus subglottic secretion drainage did not reduce tracheal colonization, but it was linked to fewer ventilator-associated pneumonia cases in critically ill intubated patients.
A large European survey found major regional and cultural differences in how clinicians approach ECLS withdrawal, with limited access to ethics and palliative care support in many institutions.
In spontaneously breathing ARDS patients on pressure support ventilation, tidal recruitment/derecruitment was strongly linked to more negative end-expiratory transpulmonary pressure, greater collapse, and non-focal infiltrates, while EIT-gu
Single-cell analysis of human severe acute pancreatitis identifies TNF-α–induced CD8+ T-cell endothelial injury as a driver of pancreatic microcirculatory failure, supporting TNF-α blockade as a potential targeted therapy.
In critically ill ICU patients with confirmed bacterial infections, appropriate empiric antimicrobial therapy was common and independently linked to lower 28-day mortality and more antimicrobial-free days.
A randomized ICU trial found oral/enteral magnesium was not proven noninferior to IV replacement for correcting mild-to-moderate hypomagnesemia, but it lowered urinary magnesium loss, cost, waste, carbon emissions, and IV fluid use.
In selected children with out-of-hospital cardiac arrest, extracorporeal CPR was associated with higher one-month survival and better neurologic outcomes than continued conventional CPR, though the study was observational and estimates were
In OPTIMAL-BP 1-year follow-up, targeting systolic BP <140 mm Hg after successful thrombectomy was associated with worse long-term functional recovery than conventional BP management.
A multi-cohort study identified four reproducible 14-day oxygenation trajectory classes in persistent acute hypoxemic respiratory failure, with distinct mortality, biomarker patterns, and links to ARDS and hyperinflammatory subphenotypes.
A MINT trial subanalysis found no evidence that ICU status changes the relative effect of restrictive versus liberal transfusion in acute myocardial infarction with anemia.
In 37 North American hospitals, proning of eligible mechanically ventilated patients increased markedly during COVID-19, then fell post-pandemic, with substantial interhospital variation throughout.
In this multicentre cohort of 207 hospitalized adults with DRESS, 17% required ICU care. Hospital-acquired DRESS and greater clinical severity independently predicted ICU admission, while ICU mortality reached 20%.
In a retrospective cohort of high-risk medical inpatients, frequent ambulatory care use before admission emerged as a predictor of harmful diagnostic error, highlighting a potentially actionable EHR-based signal for hospital diagnostic safe
A randomized ICU trial found that sitting spontaneously breathing patients in an armchair for 3 hours improved oxygenation more than staying semi-recumbent in bed, with no serious adverse events.
In a binational registry study of 615,719 ICU admissions, ICU readmission was linked to a similar absolute increase in 60-day mortality in frail and nonfrail patients, although frail readmitted patients had the highest overall mortality.
ABRUPT2 found that adding 5% albumin to lactated Ringer’s significantly reduced fluid needs in the first 48 hours after major burns, without clear differences in mortality, kidney injury, or healing time.
A large CCCTN analysis found major institutional and patient-level variation in vasoactive drug selection for cardiogenic shock, highlighting persistent evidence gaps in choosing dobutamine, milrinone, and other vasoactive therapies.
More than half of ICU caregivers in a multicenter U.S. study reported difficulty paying for patient care, and financial strain was linked to higher posttraumatic stress, anxiety, depression, decisional regret, and medical mistrust.
A new SCCM–ESICM Delphi consensus standardizes clinical criteria for refractory septic shock, focusing on persistent hypoperfusion, fluid unresponsiveness, high vasopressor needs, and bedside ultrasound when mixed shock is suspected.
