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This study reveals that acute hypoxemic respiratory failure (AHRF) affects half of ICU patients needing respiratory support, with severity linked to worse outcomes. Lung-protective ventilation is common, underscoring the need for standardiz
This review explores how the human microbiome influences management and outcomes in critically ill patients, emphasizing gastrointestinal microbial dynamics, disruption by critical illness and therapies, and emerging interventions to restor
The ENCHANTED trial post hoc analysis reveals body weight does not alter alteplase dose effectiveness in acute ischemic stroke, but low body weight independently predicts poorer outcomes without increased hemorrhagic risk.
The TRANSPORT trial showed no superiority of liberal versus restrictive RBC transfusion in septic shock patients with cancer, highlighting no mortality benefit and increased thrombotic events with liberal strategy, underscoring the need for
This study identifies baseline frailty, organ dysfunction severity, and corticosteroid use as independent predictors of severe post-intensive care frailty in older septic shock survivors, highlighting critical factors for targeted post-ICU
This study demonstrates the lack of mechanistic specificity of clinical capillary leak indices in heart failure patients, underscoring their limitations as universal markers of endothelial permeability beyond acute inflammatory states.
This study reveals how respiratory system elastance influences the effects of tidal volume and respiratory rate on outcomes in mechanically ventilated acute brain injury patients, suggesting personalized ventilation strategies based on resp
This review examines informed consent patterns and predictors in an international ICU trial on stress ulcer prophylaxis, highlighting the shift to deferred consent, pandemic influences, and implications for critical care research ethics.
This bibliometric study reveals persistent gender disparities in authorship of critical care publications, with women better represented in low- and middle-income countries and a modest increase in female authorship from 2018 to 2022 global
Admission eosinopenia (≤10 cells/μL) in adults with community-acquired pneumonia is associated with higher ICU admission, mechanical ventilation rates, and longer hospital stays, suggesting its utility as a biomarker for hospital resource p
A randomized clinical trial comparing individualized versus standard blood pressure control during mechanical thrombectomy for ischemic stroke showed no significant difference in 90-day functional outcomes or safety.
This article explores hyperinflammatory and hypoinflammatory phenotypes in severe pneumonia, their clinical impact, and translational mouse models that inform precision therapeutic strategies.
This study evaluates how ICU room characteristics, including room type and visibility, influence mortality and length of stay, finding single rooms increase length of stay without affecting mortality.
Early surgical excision within 48 hours significantly lowers 90-day mortality in adults with severe burns, suggesting it as a beneficial strategy despite increased sepsis risk.
Pre-liver transplantation elevated serum renin levels correlate with increased intraoperative vasopressor use and postoperative acute kidney injury, suggesting its potential as a predictive biomarker for perioperative management and renal r
Early initiation of insulin within two hours for moderate hyperglycemia in ICU patients significantly lowers 30-day mortality compared to delayed or no insulin therapy. This target trial emulation highlights the potential clinical benefit o
A multicenter cohort study shows that in critically ill patients undergoing continuous renal replacement therapy, mortality is more closely associated with fluid balance changes than net ultrafiltration rate, emphasizing patient-specific fl
The SAVE-O2 AI trial demonstrates autonomous oxygen titration significantly improves normoxemia maintenance and reduces hypoxemia duration compared to manual methods in hospitalized acutely ill adults.
Nearly half of psychoactive medications newly prescribed after ICU stays in American adults lack documented diagnostic justification, persisting for up to two years post-hospitalization.
A judgment-based binary triage system demonstrated high sensitivity and low undertriage rates in military trauma, supporting its use despite significant overtriage under combat conditions.
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