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The FiiRST-2 trial found no superiority of clotting factor concentrates over frozen plasma for initial resuscitation in severely bleeding trauma patients, with similar transfusion needs and safety outcomes.
This analysis compares end-tidal CO2 trends between laryngeal tube and endotracheal intubation in out-of-hospital cardiac arrest, revealing no significant difference in absolute values but highlighting complex interactions affecting return
A recent randomized clinical trial comparing augmented to conventional blood pressure targets in acute spinal cord injury found no improvement in 6-month neurological outcomes, challenging current practices and highlighting risks of higher
An international trial comparing proportional-assist ventilation (PAV+) with pressure-support ventilation (PSV) showed no significant difference in time to successful liberation from mechanical ventilation among critically ill adults.
A comprehensive international trial showed that proportional-assist ventilation (PAV+) does not significantly shorten the time to liberation from mechanical ventilation compared to pressure-support ventilation (PSV) in critically ill adults
This article reviews findings from the CLOVERS trial analyzing endothelial glycocalyx degradation in sepsis, demonstrating its strong association with mortality but showing no impact of liberal versus restrictive fluid resuscitation strateg
The PROLABI trial assessed lung-protective ventilation in acute brain injury patients and found no improvement in mortality, ventilator dependency, or ARDS incidence, highlighting the need for further research in this population.
Sudden death, often caused by heart conditions, is typically the culmination of gradual damage. This article explores warning signs, emergency response, and crucial prevention strategies to protect your heart and save lives.
A nurse-led, interprofessional family support intervention in ICUs modestly increased family satisfaction and significantly improved communication quality and emotional support, addressing a critical gap in family-centered critical care.
This article provides ten practical tips for palliative care clinicians to optimize consultation effectiveness in ICUs, emphasizing collaboration, communication, cultural respect, conflict resolution, and transition planning to improve pati
This multicentre trial shows sequential use of COX-2 inhibitors parecoxib and imrecoxib significantly reduces severe acute pancreatitis (SAP) incidence, shortens organ failure duration, lowers local complications, and decreases 30-day morta
Analysis of WHO data reveals declining global pulmonary embolism mortality overall, with marked differences by region and income, highlighting urgent needs in lower-middle-income countries.
Recent research confirms that antibiotic exposure doubles the risk of hospital-onset Clostridioides difficile infection (CDI), especially in non-carriers, underscoring the central role of antibiotic stewardship and the need for additional p
Elevated CRP levels independently predict short-term mortality in acute myocardial infarction complicated by cardiogenic shock, with extracorporeal life support showing no survival benefit regardless of CRP levels or admission timing.
A recent double-blind RCT shows iloprost did not reduce organ failure severity in septic shock patients with persistent hypoperfusion, highlighting challenges in improving outcomes despite theoretical benefits in microcirculation.
A randomized trial evaluating Normosol-R versus lactated Ringers in critically ill adults found no significant difference in acid-base balance, kidney replacement therapy rates, or 30-day mortality, supporting comparable efficacy between th
The UK-ROX randomized trial (n=16,500) found that targeting SpO2 90% (88–92%) to reduce oxygen exposure did not reduce 90‑day all‑cause mortality versus usual care in mechanically ventilated adults.
This trial demonstrates that a ketogenic diet safely induces stable ketosis in sepsis patients, improving metabolic parameters and immune regulation without adverse effects, suggesting potential benefits for sepsis-related organ dysfunction
A randomized trial assessing the impact of Nurse-Family Partnership home visits on child health and utilization over two years found no significant reduction in adverse outcomes but some decrease in emergency department use.
Severe allergic reaction refers to a sudden, severe, potentially life-threatening systemic allergic reaction in the...