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This multicenter Chinese registry study reveals a high incidence of in-hospital cardiac arrest with low survival rates and highlights critical gaps in postresuscitation care and systemic factors limiting outcomes.
White blood cell count modifies mortality outcomes in sepsis patients treated with cefepime versus piperacillin-tazobactam, suggesting its potential role in guiding antibiotic selection.
A phase 2 randomized trial shows that TISA-818, an anti-inflammatory montelukast-decapeptide conjugate, is safe and may improve respiratory outcomes in ARDS patients, especially non-intubated individuals, supporting larger trials.
A decade-long analysis reveals a modest decline and delayed timing in withdrawal of life-sustaining treatment among patients with traumatic brain injury, highlighting evolving prognostic attitudes and clinical decision-making.
This review synthesizes national data from Spain (2015-2024) revealing a decline in brain death donation (DBD) offset by growth in controlled donation after circulatory death (cDCD), alongside evolving neurocritical care practices influenci
This nationwide study reveals that hospitals with higher tendencies for early tracheostomy in severe TBI patients also show increased rates of withdrawal of life-sustaining treatment, highlighting significant practice variability and its po
A Swiss study reveals ICU professionals’ perceptions, knowledge, and ethical views on brain death, highlighting knowledge gaps and the positive impact of clinical experience on understanding.
This study validates temperature-trajectory sepsis subphenotypes in a large Chinese ICU cohort, linking immune and coagulation dysfunction with mortality and highlighting differential responses to immunoglobulin therapy, particularly benefi
This bicentric study evaluates quantitative pupillary light reflex (qPLR) alongside EEG, SSEPs, and NSE for neuroprognostication in comatose post-cardiac arrest patients, revealing strong correlations but limitations in sensitivity and pred
This comprehensive 10-year ICU study reveals a low prevalence of positive pleural fluid cultures, highlights the significant link to suspected pleural infection, and associates culture positivity with higher 90-day mortality, informing targ
A randomized controlled trial demonstrates that a multicomponent pulmonary rehabilitation program markedly improves ventilator weaning success and physiological recovery in patients aged 80 and older undergoing prolonged mechanical ventilat
A nationwide prospective study shows no significant difference in survival or neurological outcomes between lidocaine and amiodarone for adult in-hospital cardiac arrest patients with refractory ventricular fibrillation or pulseless ventric
Baseline plasma sRAGE levels identify differential mortality benefits from lung recruitment in ARDS, enabling personalized ventilation strategies unlike inflammatory phenotyping. High sRAGE patients benefit from recruitment maneuvers, while
This nationwide study reveals that 26% of ICU clinicians perceive at least one patient’s care as inappropriate, linked to ethical climate and team dynamics, and predicts poorer patient outcomes including mortality and severe disabilit
ChatGPT-4o achieves high accuracy on critical care board questions but shows notable limitations in image interpretation and reasoning, posing potential clinical risks.
Integrating transesophageal lung ultrasound with resuscitative transesophageal echocardiography in mechanically ventilated shock patients improves operator-reported shock etiology identification with minimal added procedure time, suggesting
Over half of pediatric sepsis hospitalizations are preceded by healthcare visits within 7 days, highlighting a critical window for early sepsis recognition and intervention in children.
This qualitative study explores how internal medicine clinicians develop skills in discussing goals of care, revealing a progression from basic understanding to advanced, integrated communication approaches, and underscores the need for str
This review synthesizes evidence on persistent excess mortality after SARS-CoV-2 infection in people with severe mental illness (SMI) during and following COVID-19 vaccination roll-out in England, highlighting disparities in mortality risk
This nationwide Swedish study tracks shifting predictors of critical illness during different COVID-19 pandemic periods and compares them to seasonal influenza, highlighting vaccination status and age as key risk factors for severe outcomes
