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Baseline plasma sRAGE levels identify differential mortality benefits from lung recruitment in ARDS, enabling personalized ventilation strategies unlike inflammatory phenotyping. High sRAGE patients benefit from recruitment maneuvers, while
Combined analysis of the TETON-1 and TETON-2 trials confirms inhaled treprostinil significantly slows lung function decline, reduces clinical worsening and exacerbations, and improves quality of life in idiopathic pulmonary fibrosis over on
This study reveals that COPD poses a greater risk to bone health than T2DM, with combined COPD and T2DM further increasing osteoporosis and fracture risk, especially in men, emphasizing the need for targeted bone health screening.
Integrating transesophageal lung ultrasound with resuscitative transesophageal echocardiography in mechanically ventilated shock patients improves operator-reported shock etiology identification with minimal added procedure time, suggesting
An explainable machine learning model identifies bariatric surgery candidates at risk for obesity hypoventilation syndrome using seven accessible clinical variables, enhancing early diagnosis and perioperative risk management.
Monitoring chronic pulmonary aspergillosis progression using time-normalized anti-Aspergillus IgG kinetics shows promise for early detection of disease worsening, supporting timely clinical reassessment alongside imaging and microbiology.
This analysis of U.S. CF Foundation registry data reveals that inhaled antibiotics confer lung function benefits primarily in chronic Pseudomonas aeruginosa infections, but their treatment benefit has declined with CFTR modulator use. Risks
Metered-dose liquid nitrogen cryospray significantly improves quality of life and reduces severe exacerbations in COPD patients with chronic bronchitis, with a favorable safety profile demonstrated in a recent sham-controlled trial.
SHARP registry data reveal that biologic therapies improve clinical outcomes equally in severe asthma patients irrespective of smoking status, challenging prevailing prescribing hesitancy and advocating inclusive treatment approaches.
Between 2015 and 2025, non-cystic fibrosis bronchiectasis prevalence in the US primary care population increased by 133%, predominantly affecting older, white, female patients with Medicare coverage.
Quantitative CT-defined mucus plugs combined with emphysema severity stratify COPD patients into distinct subtypes that predict risk of acute exacerbations, enabling personalized risk assessment and targeted preventive strategies.
This study evaluates when thoracentesis or thoracoscopy is more cost-effective in diagnosing malignant pleural effusion in patients with prior or active malignancy, highlighting thresholds of pleural fluid cytology sensitivity guiding optim
This review synthesizes recent evidence on quantitative CT markers of mucus plugging and emphysema in COPD, highlighting their combined impact on acute exacerbation risk and clinical heterogeneity, and discusses implications for personalize
A large-scale EHR study reveals a 133% increase in non-cystic fibrosis bronchiectasis prevalence in U.S. adults from 2015 to 2025, with marked demographic disparities.
Following the 2023 US safety net policy for kidney after lung transplantation, a shift from simultaneous lung-kidney transplants to early kidney transplantation post lung transplant was observed, with improved short-term outcomes and reduce
Dupilumab treatment in moderate to severe asthma significantly reduces mucus plug burden, resolves existing plugs, limits new plug formation, and decreases plug radiodensity on CT scans, correlating with improved lung function and ventilati
The ST120 strain of Mycobacterium massiliense, prevalent in East Asia, exhibits unique genetic features linked to increased virulence and worse treatment outcomes in pulmonary disease.
This study identifies three distinct phenotypes among patients failing to wean from invasive mechanical ventilation, linking failed initial attempts, withdrawal decisions, and mortality, highlighting the need for tailored management strateg
This study demonstrates that elevated brain natriuretic peptide (BNP) post-pulmonary endarterectomy strongly predicts mortality in chronic thromboembolic pulmonary hypertension (CTEPH), providing valuable prognostic information beyond persi
A randomized trial compared high intensity interval training (HIIT) with standard moderate intensity continuous training (MICT) in fibrotic interstitial lung disease, finding no superiority of HIIT but confirming its safety and feasibility.
