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A translational study reveals ADAMTS14 as a key regulator of YAP-mediated fibroblast mechanoactivation in idiopathic pulmonary fibrosis, identifying a ADAMTS14–collagen V–focal adhesion axis that may offer new therapeutic targets.
A prospective non-randomized study found mandibular advancement devices non-inferior to CPAP in a combined efficacy-adherence measure (MDA), with higher nightly adherence and patient preference, but study design limits interpretation.
This study assesses the diagnostic benefits of concurrent EBUS-TBNA tissue sampling and liquid biopsy for next generation sequencing in NSCLC, highlighting complementary roles and implications for clinical practice.
This review synthesizes current evidence on the effectiveness of adjuvanted RSVPreF3 vaccination in reducing RSV-related hospitalizations among older US adults, highlighting substantial protection across high-risk subgroups.
This study elucidates distinct cellular expression patterns of IL-33 and its receptor variants ST2L and sST2 in COPD lungs, highlighting mast cells and endothelial cells as key mediators in the distal lung immune response.
This post hoc analysis of the Neotorch phase 3 trial demonstrates that adding toripalimab to chemotherapy perioperatively in stage III resectable NSCLC improves tumor and nodal downstaging, reduces surgery cancellation, and significantly en
This study examines whether high-flow nasal cannula oxygen during breaks from noninvasive ventilation post-extubation reduces extubation failure compared to standard oxygen therapy in high-risk patients.
The ESRA trial demonstrates that riociguat is safe and effectively reduces pulmonary vascular resistance in early pulmonary vascular disease, though secondary benefits remain unproven in this early-stage, mostly connective tissue disease-as
A comprehensive single-cell atlas of lung immune cells reveals distinct immune responses in mild versus severe influenza, highlighting neutrophil dysfunction and lymphocyte impairment as key drivers of pathology.
BACH1 stabilization under hypoxia promotes pulmonary hypertension by enhancing TGFBR2/SMAD pathway activity in pulmonary artery smooth muscle cells, suggesting BACH1 as a promising therapeutic target for PH.
The Phase 2 TREASURE trial investigated the safety and efficacy of adding consolidative thoracic radiotherapy to atezolizumab maintenance in extensive-stage small cell lung cancer, revealing increased toxicity without survival benefit, unde
A cohort study reveals that swimming-induced pulmonary edema (SIPE) is associated with transient mild cardiac dysfunction and elevated biomarkers, distinguishing it from asymptomatic swimmers and guiding acute assessment strategies.
Activation of the prostaglandin I2 receptor (IP) enhances alveolar epithelial regeneration by promoting AT2-to-AT1 cell transdifferentiation through modulation of the JUN/p53 signaling axis, offering a promising therapeutic avenue for lung
Hypoglossal nerve stimulation markedly reduces hypoxic burden in obstructive sleep apnea patients, correlating with improved daytime sleepiness independent of AHI changes, suggesting hypoxic burden as a complementary treatment outcome metri
The CASTL trial evaluated efficient combinations of tobacco cessation interventions for smokers undergoing lung cancer screening, identifying loss-framed messaging with nicotine replacement therapy as the most cost-effective strategy.
Genetic risk loci for idiopathic pulmonary fibrosis (IPF) identified in East Asian populations largely overlap with those found in Europeans, though allele frequencies and effect sizes differ, highlighting shared ancestry and disease mechan
A cluster randomized trial in Toronto nursing homes found that on-site multiplex PCR testing improved viral detection and reduced emergency department transfers during respiratory outbreaks, though it did not alter outbreak size or frequenc
This study compares radiation doses to operators and staff during conventional and robotic bronchoscopy procedures, revealing higher exposure with robotic bronchoscopy using C-arm-based tomosynthesis but no difference with standard fluorosc
This article reviews a novel Bayesian joint mixed-effects model for analyzing lung function decline and mortality in fibrotic ILD, improving accuracy in estimating disease progression and treatment effects in clinical settings.
This study elucidates how KLF9 mediates intermittent hypoxia-induced MASLD by suppressing NR4A1 and p38 MAPK signaling, paving the way for targeted therapies in OSA-associated metabolic liver disease.
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