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Clinical Updates

Gabapentin for Cough in Idiopathic Pulmonary Fibrosis: Efficacy and Safety Insights from a Randomized Controlled Trial

MedXY Editorial TeamAug 31, 2026
chronic coughGabapentinIdiopathic Pulmonary Fibrosisclinical trial

Highlights

  • Gabapentin significantly improves cough symptoms in idiopathic pulmonary fibrosis (IPF) patients compared to placebo with a substantial increase in cough relief rate.
  • The safety profile of gabapentin in IPF cough includes manageable adverse effects such as drowsiness and dizziness, occurring in approximately one-third of treated patients.
  • These findings align with CHEST expert panel suggestions endorsing neuromodulators like gabapentin for refractory cough in interstitial lung disease (ILD), addressing an unmet therapeutic need.

Background

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