Advanced Right Ventricular Phenotyping Enhances Risk Stratification in Pulmonary Arterial Hypertension Follow-Up

Highlight

• Echocardiography-derived right ventricular (RV) phenotypes identify distinct patterns of RV remodeling and dysfunction in pulmonary arterial hypertension (PAH) patients at first follow-up.
• Four defined RV phenotypes correlate with mortality risk across ESC/ERS and REVEAL 2.0 risk categories, enhancing prognostic discrimination.
• Severely dilated RV with poor RV-pulmonary arterial coupling (phenotype-4) predicts worse outcomes independently of established risk scores.
• Mildly dilated RV with preserved coupling (phenotype-1) identifies better survival notably within intermediate risk groups, facilitating more personalized management.

Study Background