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This study demonstrates that initiation of elexacaftor/tezacaftor/ivacaftor (ETI) therapy in children and adolescents with cystic fibrosis improves continuous glucose monitoring (CGM) metrics, correlating with better clinical outcomes.
Large-scale GWAS highlight novel genetic loci influencing childhood blood pressure and heart rate, with polygenic risk scores predicting adult cardiometabolic outcomes, underscoring the importance of early-life genetic determinants in cardi
The VRONI study demonstrates the feasibility and effectiveness of combined biochemical and genetic screening for familial hypercholesterolaemia (FH) in children, revealing a higher FH prevalence than previously reported and supporting natio
A Danish multicentre trial demonstrates that individualized, clinically guided antibiotic treatment lasting around 3 days is as safe as the standard 5-7 days in late-preterm and term neonates with culture-negative early-onset sepsis, signif
This review synthesizes phase 2 and 3 trial data demonstrating that the pentavalent MenABCWY vaccine is immunologically non-inferior and well tolerated compared with MenB-fHbp and MenACWY-CRM vaccines, offering a simplified, effective vacci
This study examines the relationship between children’s and parents’ screen use and language development in children aged 5 to 7 years, finding parental smartphone use may slow vocabulary growth, while device ownership correlate
This large prospective cohort study found no significant association between prenatal organophosphate pesticide exposure and autism-related traits in children, after comprehensive adjustments including maternal diet and sociodemographic fac
Late-onset sepsis (LOS) incidence among very preterm infants declined from 2010 to 2017 but has risen since, driven mainly by increasing infections from non-CoNS gram-positive bacteria and gram-negative pathogens, notably Staphylococcus aur
Routine DAT offers limited additional clinical value over transcutaneous bilirubin monitoring in low-risk ABO and RhD-incompatible neonates, supporting guideline shifts towards selective DAT use and emphasizing maternal antibody screening.
This article reviews the variability and comparative effectiveness of re-induction treatments in pediatric relapsed AML, highlighting the role of gemtuzumab ozogamicin and chemotherapy backbones in improving remission rates but not overall
This study demonstrates that classifying a Functional Status Scale score of 7 as normal underestimates long-term disability in injured children, advocating for revised scoring cutoffs and routine follow-up assessments to enhance outcome det
Pediatric ICU admissions in the U.S. have increased significantly from 2001 to 2022, with rising complexity and costs, highlighting the need for expanded critical care resources and regionalized care.
The Bone Health Index (BHI), derived from metacarpal radiographs, predicts fracture risk more effectively than DXA in children with Osteogenesis Imperfecta, especially infants under five where DXA is limited.
This article discusses a novel machine learning-based tool, especially XGBoost, to predict hearing loss risk in high-risk neonates using clinical factors for targeted early intervention.
This study compares HOTV and tumbling E vision tests in children aged 3 to 15, demonstrating HOTV’s superior accuracy and suitability for children under 8, potentially reducing unnecessary referrals in pediatric vision screening.
Lower ventricular chamber stiffness predicts adverse outcomes in Fontan patients, revealing a high-compliance, eccentric remodeling phenotype distinct from traditional stiffening hypotheses.
This article explores ethical dilemmas in pediatric endocrinology through case studies, applying the four-principle framework to guide clinicians in managing complex patient scenarios effectively and compassionately.
This study evaluates the eligibility of children with acute ischemic stroke (AIS) for thrombolysis with tPA, revealing only 19% potential eligibility under current guidelines, and highlights opportunities to reconsider treatment in small-ve
This study reveals that among term births, fetal size at birth more strongly predicts long-term neurodevelopmental outcomes than gestational age, with small-for-gestational-age infants demonstrating persistent academic challenges into adole
The PURSUE multicenter study demonstrates that implementing Enhanced Recovery After Surgery protocols in pediatric patients undergoing complex lower urinary tract reconstruction significantly improves adherence to perioperative care standar
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