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This study analyzes EBV infection and PTLD incidence in pediatric haploidentical HSCT, identifying prior CAR-T therapy, CMV viremia, and TBI conditioning as significant risk factors, with implications for enhanced monitoring and preemptive
Childhood exposure to siblings with Crohn’s disease significantly raises disease risk, linked to distinct gut microbiome changes that may drive disease onset through immune modulation.
A French longitudinal study finds no increased long-term complications or compromised quality of life in children under 4 years undergoing TBI-based HSCT for acute lymphoblastic leukemia, challenging prior age restrictions.
In pediatric myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), escalation of acute immunotherapy beyond steroids at first attack is linked to significantly fewer relapses within one year and mid-term follow-up, highli
A longitudinal study shows no association between fecal short-chain fatty acid levels during pregnancy and early childhood with the progression to islet autoimmunity in children at risk for type 1 diabetes.
Children with perinatal brain injury exhibit lower long-term success rates following strabismus surgery, mainly due to undercorrection despite comparable surgical dosing. Larger preoperative deviations predict poorer outcomes, underscoring
This review synthesizes evidence on paternal valproate exposure and offspring neurodevelopmental risks, highlighting recent large cohort data that challenge prior concerns of increased neurodevelopmental disorders or congenital malformation
This study investigates how the timing of primary palate repair before 15 months influences early speech outcomes, finding that even slight delays increase the risk of passive cleft speech characteristics by age 36 months.
A multicenter study demonstrates the safety and effectiveness of MED-EL cochlear implants in children under 12 months and in 12-71 month-olds with residual hearing, supporting expanded pediatric CI candidacy.
Circulating miR-1-3p levels rise before clinical signs of adrenarche and regulate adrenal steroid hormone production through protein kinase C signaling pathways.
Emerging evidence from prospective birth cohorts reveals a dose-dependent association between early respiratory infections and the risk of childhood atopic dermatitis, independent of genetic predisposition and antibiotic exposure.
A pooled analysis from 22 countries demonstrates that rotavirus vaccination is highly effective in preventing rotavirus-positive acute gastroenteritis deaths in children under five, underscoring the vaccine’s critical role in reducing
This cohort study links changes in emergency department pediatric readiness and inpatient pediatric services over ten years with excess child mortality, highlighting the critical role of hospital preparedness in pediatric survival.
A 2-week-old neonate developed congenital tuberculosis despite an asymptomatic mother, illustrating diagnostic challenges and the need for heightened awareness of TB in pregnancy.
Elevated glucocorticoids, androgens, and progesterone metabolites, combined with high BMI and stress, accelerate the onset of puberty in girls, particularly breast development (thelarche).
Rigosertib demonstrates significant reversal of hypertrophic cardiomyopathy and other syndromic features in Noonan syndrome models, highlighting its potential as a targeted therapy for RASopathy-associated cardiac and developmental abnormal
Pediatric button battery ingestions increased over 15 years, with larger batteries and more esophageal impactions. Delays in caregiver recognition drive prolonged exposure, contributing to serious complications. Public awareness is crucial
This study reveals how HIF2 activation drives coronary artery remodeling, inflammation, and thrombosis in a mouse model mirroring severe Kawasaki disease, uncovering new therapeutic targets for coronary complications.
The NEAT phase 3 trial evaluated erythrocyte-encapsulated dexamethasone sodium phosphate in children with ataxia telangiectasia aged 6–9 years, confirming safety but failing to demonstrate statistically significant neurological improvement
This longitudinal study characterizes symptom variability and outcomes of respiratory infections among young children, revealing age-specific severity patterns and notable differences between influenza A and B.
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