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This review synthesizes current evidence on neurodevelopmental outcomes after treating retinopathy of prematurity with anti-VEGF injections versus laser photocoagulation, finding no significant differences in long-term cognitive or developm
Pediatric and young adult survivors of differentiated thyroid cancer face a significant long-term risk of second primary malignancies, especially with radioactive iodine treatment, highlighting the need for extended surveillance and tailore
This nonrandomized clinical trial demonstrates the surgical feasibility of fetoscopic spina bifida repair using a human umbilical cord meningeal patch, showing comparable perinatal outcomes to open repair while enabling vaginal delivery and
This review synthesizes evidence linking smartphone acquisition and use at age 13 to depression, obesity, and sleep insufficiency at age 14, highlighting that use intensity rather than mere acquisition mediates health risks, with behavioral
A 14-year follow-up of twins exposed prenatally to 17-OHPC shows no significant effects on mortality, cognition, or development, indicating its long-term safety in multiple pregnancies.
We report five pediatric MEN2B cases highlighting early extra-endocrine signs such as persistent constipation and alacrimia, enabling prompt genetic diagnosis and thyroidectomy before medullary thyroid carcinoma progression.
A national study reveals significant variability across EMS agencies in decisions about resuscitation futility and termination for pediatric out-of-hospital cardiac arrests, highlighting critical impacts on care and outcomes.
Early exclusive enteral feeding in preterm infants is associated with faster feeding advancement and shorter hospital stay without increased risks of necrotizing enterocolitis or infection, suggesting it is a feasible and beneficial nutriti
A phase II basket trial demonstrates that vosoritide significantly increases growth velocity in children with RASopathies, ACAN, and NPR2 deficiencies, with an acceptable short-term safety profile, suggesting its potential as a precision th
This multicenter study reveals improved outcomes in fetal cardiomyopathy, highlights genetic underpinnings in one-third of cases, and identifies fetal hydrops and extracardiac anomalies as key prenatal risk factors for mortality.
This review synthesizes evidence on dual-sided composite defocus (DSCD) spectacle lenses, demonstrating significant myopia progression reduction and axial elongation control in children, contextualized within broader spectacle-based interve
A multicategory study reveals 2.5% of pediatric IBD patients harbor IL-10-neutralising autoantibodies associated with severe disease and HLA-DRB1*01:03 allele, underscoring a distinct pathogenic subgroup.
This multicenter study identifies peripheral blood stem cell use as a key risk factor for early inflammatory complications post-haploidentical HSCT in children, linking these events to refractory acute and chronic graft-versus-host disease.
Temple syndrome is an under-recognised imprinting disorder with complex endocrine and growth abnormalities. This large-cohort study clarifies its phenotype, highlights growth hormone therapy benefits, and proposes a novel clinical scoring s
This multicenter observational study demonstrates that ultrasound-guided supraclavicular brachiocephalic vein cannulation is a feasible, safe, and reproducible method for central venous catheter placement in critically ill neonates, with a
A multimodal human factors program enhances team communication, nontechnical skills, and workflow during pediatric airway endoscopy, supporting OR culture change despite unchanged immediate clinical outcomes.
This study prospectively characterizes voice changes over 12 months in transmasculine adolescents and young adults receiving testosterone therapy, demonstrating significant lowering of pitch, improved voice congruence, and reduced anxiety,
Prophylactic thyroidectomy in children with MEN2 mutations shows excellent short-term cancer control but carries notable risk of permanent hypoparathyroidism, especially under age 5, highlighting the need for expert multidisciplinary surgic
Population-based genetic screening and prospective follow-up of at-risk children reduce the severity of type 1 diabetes at diagnosis and enhance one-year treatment outcomes, including lower HbA1c and insulin requirements.
This nationwide UK study identifies key factors contributing to delayed diagnosis in childhood non-infectious uveitis, underscoring the need for improved primary care awareness and streamlined referral pathways to prevent vision-threatening
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