Section
This review synthesizes long-term immunogenicity data from a South African RCT comparing 1+1 and 2+1 infant PCV10 and PCV13 schedules. PCV13 1+1 schedules maintain durable immunity up to age 5, supporting schedule optimization in establishe
A longitudinal study identifies distinct adult functioning profiles in individuals born very preterm or with very low birth weight, highlighting cognitive ability in childhood as a key predictor of positive adult socioeconomic and social ou
This phase 3 trial demonstrates that clesrovimab, a long-acting monoclonal antibody, is safe and well-tolerated in infants at risk for severe RSV disease across two consecutive RSV seasons, supporting its role in extended RSV prophylaxis.
A large-scale randomized trial demonstrates that 38% silver diamine fluoride effectively arrests dentin caries lesions in young children with severe early childhood caries, offering a safe, noninvasive treatment option and supporting FDA ap
Despite guidelines recommending judicious CT use for pediatric mild TBI, national data from 2017-2023 show persistently high and variable imaging rates across hospital types, underscoring gaps in guideline adoption and the need for targeted
Updated meta-analysis reveals modest HbA1C improvements with behavioral interventions in youth with type 1 diabetes, highlighting the superiority of family-focused, multicomponent approaches over single-focus programs.
This study identifies serum and gene expression signatures predicting successful canakinumab tapering in systemic juvenile idiopathic arthritis, offering precision medicine strategies to reduce flares.
This study highlights dupilumab’s long-term effectiveness and safety in managing pediatric atopic dermatitis over 3 years, revealing age-related differences in symptom control and treatment persistence.
This analysis of the 4-year PEDISTAD registry reveals dupilumab’s superior effectiveness and comparable safety in treating moderate-to-severe atopic dermatitis in children across diverse racial groups.
A hybrid RCT among 630 Latino caregiver-infant dyads demonstrates that text messaging and community resource referrals augment primary care literacy promotion, improving language, social-emotional development, and parenting behaviors.
This study identifies clinical and sociodemographic factors correlated with subsequent suicide attempts and mental health-related ED visits in youth screened positive for suicide risk in emergency departments, highlighting crucial targets f
Autism spectrum disorder (ASD) does not independently affect postoperative length of stay or complication rates after gastrostomy tube placement in children. Instead, outcomes are more strongly influenced by developmental delay and preopera
A new tracheostomy-specific risk-tier system improves outcome prediction in pediatric tracheostomy hospitalizations compared with traditional severity metrics, offering better benchmarking for clinical care across institutions.
This study evaluates the long-term improvement in swallowing function among children following surgical repair of Type I laryngeal cleft, demonstrating continued recovery across swallowing phases over several years.
This study reveals a significant decline in pediatric otitis media with effusion surgeries during COVID-19 in Japan, except among high-risk groups, highlighting differing drivers of disease and guiding surgical prioritization in crises.
Over half of pediatric sepsis hospitalizations are preceded by healthcare visits within 7 days, highlighting a critical window for early sepsis recognition and intervention in children.
This retrospective study found no significant seasonal variation in pediatric epistaxis referrals and management, challenging the common belief that nosebleeds peak in dry, winter months and suggesting year-round patient counseling.
This report discusses four patients with paternally inherited 15q11.2-q13 duplications linked to MKRN3 overexpression, presenting with delayed puberty and varying degrees of hypogonadism.
This study demonstrates that higher airway opening index (AOI), measured by capnography during pediatric CPR, correlates with improved survival and neurological outcomes. AOI is a novel, quantitative marker of airway patency linked to post-
An international study of 715 pediatric patients with differentiated thyroid carcinoma identifies key predictors of invasive disease and demonstrates stable outcomes despite recent therapy deintensification.
