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This study found that younger age, better baseline vision, smaller hemorrhage size, and thicker subfoveal choroid predicted better 1-year visual outcomes after fovea-involving submacular hemorrhage from nAMD or PCV.
In patients with unilateral exudative AMD, double-layer sign on OCT was common, but OCT angiography showed nonexudative macular neovascularization in only about 40% of DLS-positive fellow eyes.
A 2026 Ophthalmology study suggests that combining CTG18.1 expansion testing with a FECD-specific polygenic risk score can improve prediction of keratoplasty risk across independent cohorts.
A rare, severe neurologic complication has been linked to general anesthesia in patients of maternal Venezuelan descent. Ophthalmologists should screen for ancestry and family history, involve anesthesiology early, and consider genetic eval
Optical genome mapping and long-read sequencing uncovered a tiny balanced rearrangement that separated PAX6 from its control region, explaining classic aniridia after prior testing was negative.
A double-blind randomized trial found that a single intraoperative intravitreal bevacizumab injection improved 3-year trabeculectomy survival and reduced postoperative medication needs versus placebo.
In a large retrospective glaucoma cohort, delayed follow-up was common yet was not generally associated with visual field worsening, although longer delays appeared more consequential in eyes with worse baseline visual field loss.
This review synthesizes evidence on improving geographic atrophy trial efficiency through innovative run-in phases, single-arm designs, and superior functional biomarkers like microperimetry to reduce required sample sizes.
A new consensus statement advises cautious, shared decision-making about GLP-1 receptor agonists and NAION risk, noting that current evidence is observational, conflicting, and suggests any absolute risk increase is small.
This review evaluates 30 years of clinical outcomes for monocular congenital cataracts, revealing stagnant visual acuity results, high surgical burdens, and significant rates of secondary glaucoma and nystagmus despite surgical advances.
A multicenter study found FOXC1 duplications in multiple glaucoma families, strongly linked to juvenile open-angle glaucoma with high penetrance and variable eye and subtle systemic features, supporting routine copy-number testing in select
A large IRIS Registry study found that pigmentary glaucoma undergoes more glaucoma procedures than POAG and has higher early failure after LTP and MIGS, with notable racial differences in disease severity.
In two prospective cohorts of active, glucocorticoid-resistant thyroid eye disease, tocilizumab improved eye inflammation, proptosis, diplopia, and quality of life with acceptable safety, supporting IL-6 blockade as a promising second-line
Study identifies distinct clinical patterns in Japanese patients with RPGRIP1 mutations: Leber congenital amaurosis shows severe early vision loss while achromatopsia features progressive degeneration. Exon 18 deletion emerges as a founder
The Amblyopia Navigator offers evidence-based guidance for eye care professionals to improve early detection and treatment of childhood amblyopia, addressing specialist shortages through accessible digital tools.
This review synthesizes clinical evidence for CPN 0.05% (BYQLOVI®), highlighting its rapid efficacy, superior pain resolution, and favorable safety profile compared to traditional ocular steroids following cataract surgery.
A large multicenter study found that MIPS measure 191 captures high cataract surgery success rates but excludes many patients and may require case-mix adjustment to support fair surgeon comparisons.
In a large TriNetX retrospective cohort, prescribed NSAID use was associated with a lower subsequent risk of AMD, including both non-exudative and exudative disease, though residual confounding limits causal inference.
Study reveals storing glaucoma eyedrops in kitchens or bathrooms improves adherence by 60-70% compared to bedrooms, with evening doses most frequently missed. Environmental factors like lighting showed minimal impact.
A large French case series found pathogenic or likely pathogenic germline MBD4 variants in 23 of 896 patients with uveal melanoma, corresponding to a 31-fold relative risk versus the general population.
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