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MedXY News/Ophthalmology

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Ophthalmology

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Clinical Updates

Efficacy and Safety of Dual-Sided Composite Defocus Spectacles for Pediatric Myopia Control: A Comprehensive Evidence Review

This review synthesizes evidence on dual-sided composite defocus (DSCD) spectacle lenses, demonstrating significant myopia progression reduction and axial elongation control in children, contextualized within broader spectacle-based interve

Aug 12, 2026
Superintelligence

Comparative Performance of Four AI Systems for Detecting Referable Diabetic Retinopathy in Tanzania: A Real-World Evaluation

This study evaluates four commercially available AI systems for diabetic retinopathy screening in Tanzania, demonstrating high sensitivity for referable and proliferative DR and highlighting considerations for implementation in low-resource

Aug 12, 2026Sign in to read
news

PRISM Framework: A Comprehensive Staging System for Open-Angle Glaucoma and Risk Stratification

This article presents the PRISM model, a unified glaucoma classification integrating risk profiling, structural imaging, functional testing, and disease progression to enhance diagnosis and inform treatment strategies for open-angle glaucom

Aug 11, 2026
news

Predicting Progression in Intermediate AMD: The Crucial Role of Ellipsoid Zone Integrity and Quantitative OCT Biomarkers

Quantitative OCT biomarkers, especially ellipsoid zone integrity and hyperreflective foci, strongly predict 2-year progression from intermediate to advanced atrophic AMD, offering potential for early risk stratification and targeted interve

Aug 11, 2026Sign in to read
news

Optimizing IOL Power Calculation After Myopic Laser Vision Correction: Insights from a Multicenter Evaluation of 14 Formulas with Posterior Corneal Curvature Consideration

This large multicenter study demonstrates that modern intraocular lens power formulas, particularly those incorporating posterior corneal curvature, provide superior refractive prediction accuracy in eyes with prior myopic laser vision corr

Aug 10, 2026Sign in to read
news

Identifying Risk Factors for Progression from Primary Angle Closure Suspect to Primary Angle Closure: Insights from the ANA-LIS Trial

This post hoc analysis of the ANA-LIS trial elucidates key anterior segment anatomical and clinical predictors—including baseline intraocular pressure and plateau iris configuration—that increase the risk of progression from primary angle c

Aug 10, 2026
Diabetes & Endocrinology

Crowded Optic Discs and Risk Stratification of NAION in GLP-1 Receptor Agonist Users: Insights from a Large Multicenter Study

This large multicenter study reveals that nonarteritic anterior ischemic optic neuropathy (NAION) patients exposed to GLP-1 receptor agonists exhibit similar optic disc crowding compared to nonexposed patients, with smaller cup-to-disc rati

Aug 10, 2026Sign in to read
news

Bridging the Gap: Understanding and Reducing Diagnostic Delays in Childhood Onset Uveitis

This nationwide UK study identifies key factors contributing to delayed diagnosis in childhood non-infectious uveitis, underscoring the need for improved primary care awareness and streamlined referral pathways to prevent vision-threatening

Aug 6, 2026
news

Global Axial Length Centile Charts: A New Reference for Myopia Management in Children and Adolescents

New region- and sex-specific axial length centile charts provide vital reference values for myopia monitoring and management in children, highlighting regional differences and supporting targeted interventions against rising myopia rates.

Aug 6, 2026
Diabetes & Endocrinology

Systemic Interleukin-6 Inhibition as a Novel Approach to Reduce Diabetic Retinopathy Risk and Progression

Systemic IL-6 inhibitors are linked to significantly reduced risks of diabetic retinopathy development, progression, and vision-threatening complications, suggesting therapeutic potential for diabetic eye disease.

Aug 6, 2026
Diabetes & Endocrinology

Evaluating the Risk of Anterior Ischemic Optic Neuropathy with GLP-1 Receptor Agonists in Type 2 Diabetes: Insights from a Swedish Nationwide Cohort Study

A large Swedish cohort study assesses whether glucagon-like peptide-1 receptor agonists increase the risk of anterior ischemic optic neuropathy in type 2 diabetes. Although a borderline elevated relative risk was observed, absolute incidenc

Aug 5, 2026
news

One-Year Tumor Volume Regression as a Predictor of Survival in I-125 Plaque Brachytherapy for Posterior Uveal Melanoma

Tumor volume regression at one year post-I-125 plaque brachytherapy significantly predicts overall survival in posterior uveal melanoma, with intermediate regression showing the best outcomes.

Aug 4, 2026
news

Unveiling XXYLT1 as a Novel Mendelian Gene in Inherited Retinal Dystrophy: Insights from an Integrated GWAS Approach

A genome-wide association study in Finnish and UK cohorts identifies XXYLT1 as a novel gene implicated in Mendelian inherited retinal dystrophy, expanding genetic understanding and clinical diagnostic tools for this blinding condition.

Aug 4, 2026
news

Determinants of Endothelial Cell Density One Year After DMEK: Insights from the Diabetes Endothelial Keratoplasty Study

This analysis from the DEKS trial identifies donor endothelial damage, recipient diagnosis, and intraoperative complications as key factors influencing endothelial cell density at one year post-DMEK, highlighting the importance of donor tis

Aug 4, 2026Sign in to read
news

Addressing Critical Barriers to Corneal Cross-Linking in US Keratoconus Care: Navigating the Transition from Photrexa® to Epioxa™

This article examines disparities in access to corneal cross-linking (CXL) for keratoconus patients in the US, highlighting challenges posed by high costs, insurance limitations, and the transition from Photrexa® to Epioxa™.

Aug 2, 2026
news

Increased Risk of Pseudophakic Cystoid Macular Edema After Cataract Surgery in Eyes with Prior Pars Plana Vitrectomy: Insights from a Large Retrospective Cohort Study

This study reveals that eyes with previous pars plana vitrectomy exhibit a significantly higher risk of cystoid macular edema following cataract surgery, underscoring the need for careful postoperative monitoring and potential prophylaxis s

Aug 2, 2026
Diabetes & Endocrinology

Determinants of One-Year Success in Descemet Membrane Endothelial Keratoplasty: Insights from the Diabetes Endothelial Keratoplasty Study

This article examines factors influencing the one-year success rate of DMEK in treating corneal endothelial dysfunction, highlighting the impact of operative complications and donor-recipient variables based on findings from the Diabetes En

Aug 2, 2026Sign in to read
Ophthalmology

Ocular Response Analyzer vs Goldmann Tonometry: Differences in IOP Measurement and Glaucoma Screening in a Greek Elderly Population

A population-based study comparing corneal-compensated IOP (IOPcc) with Goldmann applanation tonometry found poor agreement and significantly different prevalence of ocular hypertension, with implications for glaucoma screening.

Jul 29, 2026
Infectious Diseases

Fungal Endophthalmitis Associated with Contaminated Trypan Blue in Cataract Surgery: A Retrospective Case Series

Six cases of postoperative fungal endophthalmitis caused by Sarocladium kiliense following cataract surgery involving contaminated trypan blue are reported, highlighting diagnosis, management, and outcomes.

Jul 24, 2026
news

Increased Risk of Dry Eye Disease in Patients with Chronic Pain Conditions: Insights from a Large Retrospective Cohort Study

Chronic pain conditions significantly elevate the risk of developing dry eye disease, including cases requiring prescription therapy, emphasizing the need for integrated clinical assessment and management.

Jul 20, 2026Sign in to read
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