Crowded Optic Discs and Risk Stratification of NAION in GLP-1 Receptor Agonist Users: Insights from a Large Multicenter Study
Highlight
- Nonarteritic anterior ischemic optic neuropathy (NAION) patients exposed to GLP-1 receptor agonists (GLP-1 RA) have similar optic disc crowding as non-exposed NAION patients.
- A smaller cup-to-disc ratio (CDR) in the unaffected fellow eye is strongly associated with increased odds of developing NAION.
- Patients with a CDR ≤ 0.20 exhibit 46-fold higher odds of NAION compared to those with CDR > 0.40.
- GLP-1 RA exposure does not independently alter the risk of NAION related to optic disc morphology.
Study Background
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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.