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Stimulating TSH receptor antibodies enhance expression of TSHR and IGF-1R in fibroblasts via receptor recycling, elucidating mechanisms underlying thyroid eye disease and identifying potential therapeutic targets.
This study identifies intraoperative vitreous hemorrhage and silicone oil tamponade as significant posterior segment risk factors for graft failure post-penetrating keratoplasty, highlighting critical considerations in managing complex corn
A 12-month follow-up of the REAGIR trial found no significant benefit of adjunctive rose bengal photodynamic therapy with green light over sham treatment in improving visual acuity, scar size, or complication rates in infectious keratitis.
This study compares diagnostic-only versus combined diagnostic and treatment-based definitions of glaucoma in UK Biobank participants, revealing stronger associations of risk factors and severity biomarkers with definitions including treatm
This study evaluates the association of dopamine-enhancing drugs, especially levodopa, with lowered 3-year risk of progression from non-neovascular to neovascular AMD, offering promising insight into dopaminergic pathways in AMD management.
A large retrospective study from the IRIS® Registry reveals a modest, time-dependent increase in neovascular AMD risk following cataract surgery in patients with dry AMD, with implications for perioperative evaluation and patient counseling
A phase 2 randomized trial found that topical ripasudil after DSO improved endothelial cell density, sped edema clearance, and reduced rescue therapy in FECD, especially with QID dosing.
SS-OCTA identified retinal and choriocapillaris microvascular changes associated with cognitive status in Alzheimer disease, including thinner GCC in dementia and a biphasic CCFD pattern, suggesting a promising noninvasive biomarker platfor
A randomized trial found that an 8-week digital mindfulness app improved anxiety, depression, and stress in adults with non-infectious uveitis, but did not significantly change vision-related quality of life.
An optimized AAV5 vector delivering a stabilized human RPGR ORF15 gene significantly restores photoreceptor structure and function in RPGR-deficient mice, demonstrating a promising gene therapy for X-linked retinitis pigmentosa.
A large prospective study reveals high prevalence of strabismus and decreased stereopsis in parents of children with strabismus, underscoring familial inheritance and subclinical phenotypes useful for genetic studies.
In a large OHDSI network study of adults with type 2 diabetes, semaglutide was not associated with a higher or lower risk of neovascular age-related macular degeneration.
A new cohort study suggests ultra-widefield fluorescein angiography frequently detects persistent peripheral leakage in clinically inactive demyelinating disease-associated uveitis, highlighting a potential gap between examination-based rem
In very preterm infants, thicker retinal nerve fiber layer on OCT at 36 weeks’ postmenstrual age was associated with better motor and cognitive outcomes at 2 years, supporting retinal imaging as a potential early neurodevelopmental biomarke
A large retrospective study links higher HbA1c and elevated blood pressure to diabetic retinopathy in youth with type 1 diabetes, while worse glycemia also correlates with thinner inner retinal layers suggestive of early neurodegeneration.
A large US claims-based cohort suggests that most open-angle glaucoma suspects have modest annual conversion risk after the first year, and that age- and treatment-informed surveillance intervals may help tailor follow-up intensity.
In phase 3 testing, veligrotug produced rapid and clinically meaningful reductions in proptosis, diplopia, and disease activity in active thyroid eye disease, with durable benefit through 52 weeks and a favorable short-term safety profile.
A multicenter study found that immune checkpoint inhibitor–associated uveitis risk varies by cancer type and drug class, with melanoma showing the highest intrinsic risk and RCC risk largely linked to ipilimumab/nivolumab exposure.
A large U.S. study found that a contrast sensitivity score of 1.60 logCS marks the point where older adults are more likely to experience everyday vision disability, even when standard visual acuity may seem acceptable.
A multinational OHDSI network analysis found no meaningful association between semaglutide use and neovascular age-related macular degeneration among adults with type 2 diabetes across cohort and self-controlled designs.
