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A 2026 expert consensus defines an image-based reference standard to validate AI screening algorithms for age-related macular degeneration (AMD), endorsing Beckman grading and routine OCT use while clarifying referral thresholds and areas o
Distinct baseline foveal tomographic lesions predict foveal-first versus extrafoveal-first cRORA onset in iAMD. Hyperreflective foci and lesion type inform risk stratification and timing of atrophic progression relevant for emerging dry AMD
This study identifies heterogeneous patterns of ocular pain following LASIK and PRK, linking prolonged symptoms to surgery type and baseline factors, highlighting the need for tailored patient management.
This cohort study reveals that clonal hematopoiesis of indeterminate potential (CHIP) independently increases age-related macular degeneration (AMD) risk, with amplified effects when combined with high genetic susceptibility, especially in
A multicenter retrospective study evaluates five-year risks of systemic complications in non-infectious uveitis patients receiving biologic versus conventional therapies, highlighting infection and cytopenia risks with biologics but compara
Systemic nicotinamide supplementation is associated with reduced risk of POAG development in ocular hypertension, improved retinal function, and better quality of life, suggesting its neuroprotective potential as an adjunctive therapy in gl
This study validates the ISOLD score, a cytokine-based probabilistic tool, demonstrating high sensitivity and specificity for diagnosing vitreoretinal lymphoma from aqueous humor samples, outperforming standard IL-10/IL-6 ratios, with impli
This case series reveals a high prevalence of uncontrolled hypertension among diabetic patients visiting ophthalmology clinics and highlights the importance of in-clinic blood pressure screening to identify and manage cardiovascular risk.
This study assesses the added value of 10-2 visual field testing compared to the 24-2 test in detecting progression of early glaucoma, highlighting its role in patients with localized central visual field loss.
In unilateral noninfectious anterior uveitis, affected eyes show reduced corneal sensitivity and nerve abnormalities; importantly, the contralateral eyes also exhibit subtle nerve changes, suggesting bilateral corneal involvement.
This multicenter study validates prespecified OCT diagnostic rules demonstrating high accuracy in detecting glaucomatous optic neuropathy in nonpathologic myopic eyes, offering improved clinical decision support across diverse populations.
Medicare Advantage beneficiaries receive fewer higher-cost anti-VEGF injections compared to Fee-for-Service patients, highlighting potential access disparities to newer ophthalmic therapies.
An exploratory trial of UGX-201, a novel optogenetic therapy, demonstrated safety and meaningful visual improvements in patients with advanced nonsyndromic retinitis pigmentosa, including restoration of light perception in those previously
Avacincaptad pegol significantly reduces progression of ellipsoid zone degradation and geographic atrophy lesion growth, highlighting its potential to preserve photoreceptor integrity in AMD patients.
Stimulating TSH receptor antibodies enhance expression of TSHR and IGF-1R in fibroblasts via receptor recycling, elucidating mechanisms underlying thyroid eye disease and identifying potential therapeutic targets.
This study identifies intraoperative vitreous hemorrhage and silicone oil tamponade as significant posterior segment risk factors for graft failure post-penetrating keratoplasty, highlighting critical considerations in managing complex corn
A 12-month follow-up of the REAGIR trial found no significant benefit of adjunctive rose bengal photodynamic therapy with green light over sham treatment in improving visual acuity, scar size, or complication rates in infectious keratitis.
This study compares diagnostic-only versus combined diagnostic and treatment-based definitions of glaucoma in UK Biobank participants, revealing stronger associations of risk factors and severity biomarkers with definitions including treatm
This study evaluates the association of dopamine-enhancing drugs, especially levodopa, with lowered 3-year risk of progression from non-neovascular to neovascular AMD, offering promising insight into dopaminergic pathways in AMD management.
A large retrospective study from the IRIS® Registry reveals a modest, time-dependent increase in neovascular AMD risk following cataract surgery in patients with dry AMD, with implications for perioperative evaluation and patient counseling
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