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Childhood exposure to siblings with Crohn’s disease significantly raises disease risk, linked to distinct gut microbiome changes that may drive disease onset through immune modulation.
This study identifies fibroblast-secreted Spondin-2 as a crucial mediator promoting the transition from metaplastic to dysplastic gastric epithelial cells, advancing understanding of early gastric carcinogenesis.
This retrospective multicenter study evaluates fecal microbiota transplantation (FMT) for steroid-refractory acute graft-versus-host disease (aGvHD), demonstrating a 60.5% response at day 28 and highlighting FMT’s potential as a safe
A prospective study of 214 living liver donors undergoing robotic hepatectomy reveals excellent physical recovery and improved psychosocial wellbeing within one year post-donation, supporting the donor-centered benefits of this minimally in
Carvedilol demonstrates superior effectiveness over nadolol and propranolol in reducing portal hypertension and preventing cirrhosis decompensation events, with emerging evidence supporting its preferential use in both compensated and decom
A study reveals a higher prevalence of rapid CYP2C19 metabolizer phenotypes in GERD patients undergoing surgery versus medical therapy, supporting tailored proton pump inhibitor dosing and timely surgical referral.
This article reviews the development and validation of a reliable video-based competency assessment tool (MSA CAT) for magnetic sphincter augmentation, integral to surgical quality assurance in the GOLF trial for antireflux surgery.
A comprehensive European cohort study reveals that Helicobacter pylori infection’s association with insulin resistance is confounded by socioeconomic and lifestyle factors, arguing against its independent causal role and the need for
This article explores how autophagy in Kupffer cells influences CD8+ T cell activation and contributes to primary biliary cholangitis, highlighting potential therapeutic interventions targeting macrophage autophagy to alleviate liver inflam
CD177+ neutrophils facilitate rapid liver regeneration post-ALPPS by promoting extracellular matrix remodeling and hepatocyte growth factor release, revealing new immunological insights and potential therapeutic avenues for liver failure.
Distinct gut microbial profiles but shared metabolomic markers, especially fecal acetate, predict response and survival with combination immunotherapy in metabolic dysfunction-associated and viral hepatitis-related hepatocellular carcinoma.
PCK1 deficiency in hepatocytes drives metabolic reprogramming that fosters MASH-HCC progression by inducing CD8+ T cell dysfunction through 12-HETE-p38 signaling, highlighting a metabolic immunotherapy target to enhance anti-PD-1 efficacy.
Emerging evidence identifies KIF13B facilitating KPNA2-mediated nuclear import of PPARα as a critical mechanism to mitigate alcohol-associated liver steatosis, highlighting novel therapeutic strategies for ALD.
This article explores how intestinal flagellin drives systemic inflammation via the TLR5-IL-15-ARA pathway in long COVID, rheumatoid arthritis, ankylosing spondylitis, and IBD, highlighting potential therapeutic targets and biomarkers.
This study analyzes surgical specimens from the SANO trial, revealing that local regrowth after neoadjuvant chemoradiotherapy predominantly involves mucosa and submucosa and supports endoscopic monitoring in active surveillance, with surger
NEK7 promotes acquired lenvatinib resistance in hepatocellular carcinoma by phosphorylating EGFR at serine 1070, activating key signaling pathways. Blocking this interaction offers a promising therapeutic avenue to counteract resistance.
This study delineates three unique molecular subtypes of cholangiocarcinoma via integrated multiomic and machine learning methodologies, highlighting TNK1 kinase as a promising targeted therapy in a metabolic subtype.
NSUN6 deficiency in pancreatic cancer promotes immune suppression by enhancing immunosuppressive macrophage infiltration via the KDM5A-CCL2 axis, leading to resistance to immune checkpoint blockade; targeting this pathway offers a promising
Flagellated gut bacteria activate TLR5 on neutrophils, triggering IL-15 release and macrophage arachidonic acid production, driving systemic inflammation in long COVID, rheumatoid arthritis, ankylosing spondylitis, and IBD.
This study reveals that weight gain exceeding 5% in MASLD patients increases liver-related event risks and liver stiffness, whereas weight loss improves liver stiffness and may reduce adverse outcomes, especially with obesity reversal.
