Fecal Microbiota Transplantation: A Promising Therapy for Steroid-Refractory Acute Graft-Versus-Host Disease
gut microbiomesteroid-refractoryhematopoietic stem cell transplantationfecal microbiota transplantation
Highlight
- Fecal microbiota transplantation (FMT) showed a 60.5% overall response rate at day 28 in steroid-refractory acute graft-versus-host disease (aGvHD) patients.
- GI involvement was the primary indication for FMT, addressing gut dysbiosis linked to aGvHD pathophysiology.
- More than half of patients experienced related adverse events, yet no unexpected safety signals emerged.
- Significant secondary benefit included a 54.5% decolonization rate of antibiotic-resistant bacteria.
Study Background
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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.