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Retinoic acid-driven expansion of CD16hiCD177+ neutrophils mediates steroid-resistant gastrointestinal graft-versus-host disease (GI-GVHD). Inhibition of the retinoic acid receptor restores steroid sensitivity and improves outcomes in murin
This article reviews a novel surgical technique for adult living donor liver transplantation that enhances vascular reconstruction, significantly reduces hepatic arterial thrombosis, and utilizes the umbilical portion as an autologous graft
This multicenter prospective study reveals that colectomy in recurrent sigmoid diverticulitis improves disease-specific quality of life and reduces 1-year recurrence compared to observation, informing surgical decision-making.
A new living donor liver transplant program in the U.S. demonstrates that adult living donor hepatectomy can be safely implemented, with surgical proficiency and donor outcomes improving through accumulated experience.
This study assesses the procedural maturation and midterm durability of the posterior rectus sheath flap (PoRSHA) for hiatal reinforcement in complex paraesophageal hernias, demonstrating favorable recurrence rates and low donor-site morbid
A Europe-wide prospective study shows wide variation in morphology-based surgery for chronic pancreatitis and no clear outcome advantage from current guideline concordance — underscoring the need for unified, clearer recommendations on rese
Drug-Induced Liver Injury (DILI) remains a pivotal challenge in drug development, with evolving drug modalities and clinical trial designs prompting updated regulatory perspectives from FDA specialists.
This review examines the clinical relevance of a ≥30% decrease in VCTE-derived liver stiffness in predicting fibrosis regression in MASH, highlighting modest predictive accuracy and the need for improved biomarkers.
A nationwide cohort study reveals that in IBD patients, colorectal cancer risk increases notably with multiple affected relatives, challenging current guidelines prioritizing early-onset family history for surveillance.
This article explores how genetic variants affect CPEB3-mediated alternative polyadenylation in hepatocellular carcinoma, revealing potential prognostic markers and therapeutic targets to improve patient survival.
A comprehensive multinational study reveals that achalasia significantly raises the risk of esophageal squamous cell carcinoma independently, while its association with adenocarcinoma is modest and largely mediated by gastroesophageal reflu
A randomized controlled crossover trial found that individualized exclusion diets based on confocal laser endomicroscopy (CLE) findings do not significantly improve symptoms in irritable bowel syndrome (IBS) patients compared to sham diets.
Liver transplantation facilitates early neurocognitive recovery in end-stage liver disease patients by restoring cortical network activities, with S-methyl-5′-thioadenosine playing a pivotal neuroprotective role through modulating neu
Alpha-1 antitrypsin deficiency (AATD) Z-allele carriers, including heterozygotes and homozygotes, exhibit progressively increased risk of adverse liver outcomes, emphasizing the need for early diagnosis and vigilant monitoring.
A shift from static portal pressure thresholds to dynamic, non-invasive risk prediction models offers improved prognostic accuracy for decompensation in advanced chronic liver disease, enabling personalized patient management and better cli
CAR T cells targeting the CA19-9 glycan show potent, specific anti-tumor activity in pancreatic and various gastrointestinal cancers, providing new avenues for immunotherapy of hard-to-treat solid tumors.
This prospective cohort study compares semaglutide, bariatric surgery, and lifestyle therapy in obese patients with MASLD, demonstrating semaglutide and surgery improve liver steatosis and fibrosis markers better than lifestyle changes alon
Combined intrahepatic and periduodenal lymphatic embolization significantly improves protein balance and remission duration in congenital heart disease patients with protein-losing enteropathy compared to intrahepatic embolization alone, of
Comprehensive proteomic and phosphoproteomic profiling of 267 neuroendocrine carcinomas across multiple tissues reveals distinct molecular subtypes, biomarkers, and a novel NAD+ metabolic vulnerability, advancing personalized precision medi
This review explores how the human microbiome influences management and outcomes in critically ill patients, emphasizing gastrointestinal microbial dynamics, disruption by critical illness and therapies, and emerging interventions to restor
