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From 2017 to 2023, colonoscopy use increased notably in adults under 50. Yet, early-onset colorectal cancer rates and racial disparities, particularly among Black and Hispanic populations, worsened, highlighting that screening alone does no
The Integrative Muscle-Adipose Score (IMAS) combines muscle and fat measures into a sex-specific tool that accurately predicts long-term survival and postoperative complications in liver transplant recipients, outperforming existing models.
Kynurenic acid (KYNA) reduction in the gut correlates with worse poststroke outcomes. Supplementation activates a gut-brain neural circuit via GPR35 and the vagus nerve, promoting neuroprotection and functional recovery after ischemic strok
This UK cohort study reveals that both maternal and paternal obesity before pregnancy significantly increase offspring’s risk of metabolic dysfunction associated steatotic liver disease (MASLD) by age 24, largely mediated by excess ch
Recent research identifies intestinal serotonin 5-HT3a receptor signaling via vagal neurons as a key mediator of microbiota-induced hypertension, offering new insights into resistant hypertension and potential therapeutic targets.
An international Delphi panel concludes metabolic dysfunction‑associated steatotic liver disease (MASLD) raises colorectal cancer (CRC) risk. Experts call for earlier, risk‑adapted CRC screening and integrated metabolic care to reduce CRC b
The Rome V global epidemiology survey confirms a high prevalence of disorders of gut-brain interaction (DGBI) worldwide, consistent with prior Rome IV findings, underscoring a significant and persistent global clinical burden.
Among type 2 diabetes patients using GLP-1 receptor agonists, oxycodone is linked to higher short-term risks of severe gastrointestinal complications compared to hydrocodone and tramadol, warranting cautious opioid selection in this populat
Subclinical liver disease, marked by steatosis, fibrosis, and functional impairment, independently and synergistically increases cardiovascular disease risk. Incorporating non-invasive liver biomarkers could enhance CVD risk prediction and
NCACC technology identifies rare cIgG+ epithelial cells at liver cancer invasive fronts, revealing a STAT1-dependent signaling axis promoting aggressiveness and offering new therapeutic targets in liver cancer.
Heterozygous germline mutations in MSH3 and likely MLH3 confer an increased colorectal cancer risk through somatic second hits, inducing hypermutant, microsatellite-stable tumors characterized by signature ID4 and excess somatic deletions.
This study reveals that diabetes-related genetic risk scores predict pre-transplant diabetes status and influence metabolic outcomes one year after total pancreatectomy with islet autotransplantation in chronic pancreatitis patients.
A randomized clinical trial demonstrates that synthetic mesh reinforcement during subcostal abdominal closure notably decreases incisional hernia incidence without increasing postoperative complications, improving patient recovery after hep
Antibiotic treatment transiently improves pouchitis by suppressing exotoxin-producing bacteria, but resistant strains quickly re-emerge, driving relapse; targeted microbial approaches are needed for sustained remission.
This international cohort study evaluates hypothermic oxygenated perfusion (HOPE) versus normothermic machine perfusion (NMP) in liver transplantation, revealing comparable high graft survival despite differing donor risk profiles and highl
This study reveals how the S1P-TREM2-NRF2 signaling pathway protects tumor-associated neutrophils from ferroptosis, sustaining immunosuppression and promoting hepatocellular carcinoma progression, offering new therapeutic avenues.
A national multipayer analysis demonstrates robotic cholecystectomy offers comparable safety to laparoscopic methods while improving key outcomes versus open surgery, signaling maturation of robotic biliary surgery.
A global study identifies key hospital-level modifiable resources that reduce 90-day mortality after pancreas surgery and introduces a composite Hospital Resource Index to guide improvements beyond surgical volume centralization.
Excessive supragastric belching (SGB) occurs in nearly 20% of patients with conclusive gastro-oesophageal reflux disease, contributing significantly to acid exposure time and symptom burden. This multicentre study identifies clinical predic
Pharmacological reduction of plasminogen via antifibrinolytic agents accelerates liver regeneration after surgery in mice and decreases posthepatectomy liver failure risk in patients, representing a promising therapeutic approach.
