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This study reveals that specific gene mutations and cardiovascular risk factors significantly influence prognosis and thrombotic risk in triple-negative essential thrombocythemia, highlighting the importance of molecular profiling for perso
HERZCHECK demonstrates that mobile, telemedically supervised cardiac MRI enables early detection of subclinical preheart failure in at-risk individuals with cardiovascular risk factors in rural areas, identifying disease nearly seven years
A comprehensive nationwide study reveals that maternal diabetes during pregnancy, particularly pregestational diabetes, significantly increases offspring’s risk of early-onset cardiovascular diseases, mediated partly by perinatal comp
This study from two Spanish cohorts explores how moderate wine consumption within a Mediterranean diet impacts cardiovascular disease and mortality, suggesting modest benefits but advising cautious interpretation.
The ORBITA-CTO multicenter, randomized, placebo-controlled trial demonstrates that PCI significantly improves angina symptoms and quality of life in patients with single-vessel CTO without bystander disease, compared to placebo.
This study reveals that bisphenol F exposure aggravates cardiomyopathy under hemodynamic stress through gut microbiota metabolism, highlighting a novel gut-heart axis involving N-acetylputrescine and potential therapeutic targets.
A cohort study reveals that swimming-induced pulmonary edema (SIPE) is associated with transient mild cardiac dysfunction and elevated biomarkers, distinguishing it from asymptomatic swimmers and guiding acute assessment strategies.
Premeal insulin administration significantly lowers postprandial blood glucose and improves myocardial microvascular blood flow in young adults with type 1 diabetes, highlighting the importance of insulin timing for cardiovascular health.
A national cohort study found that adoption of the Resuscitation Quality Improvement (RQI) program for CPR training did not improve survival to discharge or return of spontaneous circulation in patients experiencing in-hospital cardiac arre
A cohort study demonstrates increased major cardiovascular event risk in first-degree relatives of individuals with high plasma lipoprotein(a), supporting cascade screening for targeted prevention.
This analysis of the China Rural Hypertension Control Project reveals that intensive blood pressure management chiefly drives cardiovascular risk reduction, with modest contributions from behavioral and metabolic changes, highlighting domai
A 5-generation French Canadian family with history of sudden cardiac death was diagnosed with calcium release deficiency syndrome using a novel burst pacing provocation test, illustrating its clinical utility and highlighting the importance
Risk-weighted apoB (RW-apoB) integrates LDL, TRL/remnants, and Lp(a) atherogenicity to improve coronary heart disease risk prediction, outperforming conventional lipid biomarkers like apoB and LDL-C in multiple population cohorts including
This study reveals that 21% of asymptomatic patients with mild HCM develop major adverse cardiovascular events over 7 years, highlighting key predictors such as age, symptom progression, and cardiac remodeling markers that inform management
Obicetrapib significantly lowers lipoprotein(a), LDL cholesterol, and apolipoprotein B in high cardiovascular risk patients, offering a promising addition to lipid-lowering therapies, especially for patients with mild to moderate Lp(a) elev
The SELUTION4ISR trial demonstrates that sirolimus-eluting balloons are a safe and effective noninferior alternative to standard care, including repeat drug-eluting stents, for treating coronary in-stent restenosis at 1 year.
Unsupervised clustering of echocardiographic and hemodynamic data in sepsis reveals four distinct cardiovascular subphenotypes, each with unique mortality risks and responses to treatment, enabling personalized shock management strategies.
A two-day stay at 2500 m altitude increases right ventricular afterload and impairs ventricular-arterial coupling but maintains oxygen delivery in stable pulmonary vascular disease patients.
Menaquinone-7 (MK-7) supplementation over two years significantly slows progression of coronary artery calcification (CAC) in symptomatic coronary artery disease patients, with favorable safety and potential implications for plaque stabiliz
The InEurHeart trial demonstrates that computed tomography-guided ventricular tachycardia ablation significantly reduces procedure duration while maintaining safety and efficacy compared to conventional methods in patients with ischemic car
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