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This study reveals how the S1P-TREM2-NRF2 signaling pathway protects tumor-associated neutrophils from ferroptosis, sustaining immunosuppression and promoting hepatocellular carcinoma progression, offering new therapeutic avenues.
This multicenter study reveals that total-body irradiation (TBI) conditioning before hematopoietic stem cell transplantation severely compromises pregnancy outcomes compared to alkylating agents or conventional chemotherapy in female surviv
This study compares outcomes after allogeneic stem cell transplantation using post-transplant cyclophosphamide in AML patients achieving first remission with one versus two induction courses, revealing similar survival but higher relapse wi
This study analyzes outcomes of azacitidine versus decitabine, with or without venetoclax, in TP53-mutant AML, revealing comparable survival outcomes and highlighting the independent prognostic impact of multi-hit TP53 status.
Circulating tumor cells (CTCs) enhance the IMS-IMWG 2025 genomic staging by identifying a disseminated high-risk phenotype in newly diagnosed multiple myeloma, improving prognostic stratification and enabling minimally invasive disease moni
This review synthesizes evidence on IL-16-driven resistance to BTK inhibitors and chemoimmunotherapy in B-cell lymphomas, highlighting the IL-16/CD9/PI3K axis as a targetable epigenetically regulated survival pathway overcoming drug resista
Arlocabtagene autoleucel (arlo-cel) is a novel GPRC5D-targeted CAR T-cell therapy showing promising efficacy and manageable safety in patients with relapsed/refractory multiple myeloma heavily pretreated with standard regimens, including pr
This study explores how intensivists conceptualize appropriate goals of care and the influences of health system factors on decision-making for patients with chronic critical illness, emphasizing predictions about quality of life and functi
The PASSAGE phase 4 study reveals tezepelumab significantly reduces exacerbation rates and improves lung function and quality of life in a broad US severe asthma population, including underrepresented groups and varied phenotypes.
Dupilumab significantly reduces emergency visits, hospital admissions, and systemic corticosteroid use in COPD patients with type 2 inflammation, offering a promising therapeutic option to mitigate exacerbation-associated morbidity.
This study elucidates how ribbon-type reticular pseudodrusen, especially when coexisting with soft drusen, significantly impair retinal sensitivity in intermediate AMD, highlighting the importance of lesion phenotype in functional risk asse
This study reveals that 30.7% of atopic dermatitis patients treated with dupilumab develop ocular surface disease, despite prevalent ocular symptoms at baseline and increased ophthalmic treatment during therapy, linked to reduced conjunctiv
Phase 3 trials show satralizumab significantly improves proptosis, inflammation, and diplopia in thyroid eye disease with a favorable safety profile, marking a new therapeutic option targeting the IL-6 receptor pathway.
This study explores the high prevalence of voice fatigue among e-cigarette users and its significant correlation with dry mouth (xerostomia).
This study evaluates the long-term sinonasal health and quality of life in children after removal of button batteries or magnets from the nose, highlighting favorable outcomes with prompt intervention and need for extended monitoring in sym
A national multipayer analysis demonstrates robotic cholecystectomy offers comparable safety to laparoscopic methods while improving key outcomes versus open surgery, signaling maturation of robotic biliary surgery.
This study highlights how early physiologic markers like shock index and hypotension can predict PTSD risk in gunshot wound survivors, while blood transfusion shows an inverse relationship, aiding targeted mental health interventions.
A large European study shows that severe anastomotic leaks requiring surgical reintervention after esophagectomy significantly reduce long-term survival and increase postoperative mortality, underscoring the need for targeted management str
A global study identifies key hospital-level modifiable resources that reduce 90-day mortality after pancreas surgery and introduces a composite Hospital Resource Index to guide improvements beyond surgical volume centralization.
This study reveals distinct alterations in the type I interferon pathway expression and signaling linked to mutated p53 subtypes in endometrial cancer, highlighting differing immune microenvironments that impact prognosis and therapeutic co
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