Section
The 2026 Second Universal Definition standardizes HF terminology, reframes ejection-fraction categories, formalizes pre-HF and dynamic HF trajectories, and offers a global, cause-based classification to improve prevention, diagnosis, resear
The NEONIPIGA phase 2 trial demonstrates durable survival and high pathological complete response rates with neoadjuvant nivolumab and ipilimumab in localized MSI-high gastric and GEJ adenocarcinoma, highlighting potential for organ-preserv
Transphyseal ACL reconstruction in patients close to skeletal maturity generally results in minimal alignment changes, but a significant subgroup shows clinically relevant valgus deformities, underscoring the need for vigilant radiographic
A six-month supervised telerehabilitation programme combining Pilates-based exercises and self-myofascial release significantly improved fibromyalgia impact, sleep quality, depressive symptoms, and stress levels compared to usual care in ad
This retrospective case series evaluates the feasibility and 1-year outcomes of using a dedicated Apex Guide with static digital workflow for root membrane preparation and immediate implant placement in 15 patients.
The RESOLVE trial demonstrates that 8 weeks of sofosbuvir-velpatasvir treatment is non-inferior to the standard 12-week regimen in treatment-naive, non-cirrhotic chronic hepatitis C patients, supporting shorter treatment duration without co
A national survey reveals wide variability in social risk screening and referral practices across pediatric inpatient settings, highlighting the need for standardized approaches to promote equitable social care for hospitalized children.
Preoperative neutrophil-to-lymphocyte ratio (NLR) predicts poor outcomes in high-risk cutaneous squamous cell carcinoma, offering a cost-effective tool to enhance risk stratification.
The Modified Liacyr-Ribeiro breast reduction technique demonstrates high patient satisfaction and lasting structural outcomes over more than 10 years, effectively preventing inferior pole descent and pseudoptosis.
A deep learning model classifying usual interstitial pneumonia patterns on CT scans predicts fibrosis progression and mortality in individuals with interstitial lung abnormalities, offering a promising tool for risk stratification and clini
A 40-year retrospective study of 569 patients with ocular metastases reveals persistently poor survival, dominated by breast and lung primaries, with vision often preserved through treatment despite no significant survival improvements over
HPV-positive keratinizing nasopharyngeal carcinoma demonstrates significantly improved overall survival compared to HPV-negative cases, underscoring the prognostic and clinical relevance of HPV testing in NPC management.
A new patient-level social determinants of health measure independently predicts advanced stage and survival outcomes in colon cancer patients, highlighting the importance of integrating social risk factors into oncologic care.
The FELICIA phase IIb trial found that adding metformin to progestin therapy for fertility-sparing treatment in endometrial neoplasia did not improve 3-year recurrence-free survival or remission rates, though some reproductive outcomes favo
Legalizing online sports betting in the US is linked to increased use of outpatient mental health services and prescription medications among insured adults, highlighting the need for focused prevention and treatment.
A province-wide quality improvement initiative in Ontario implemented a web-based Family Satisfaction in ICU (FS-ICU) survey across adult level 3 ICUs, revealing high satisfaction scores yet highlighting challenges in participation and comp
This review synthesizes evidence supporting outpatient management of acute low-risk pulmonary embolism (PE), highlighting risk stratification tools, safety outcomes, and implementation strategies to enhance adoption in clinical practice.
Resident physicians demonstrate lower breast cancer screening rates compared to faculty, even in well-supported academic practices. Adjusting for patient and physician factors narrows, but does not eliminate, this gap, underscoring the need
Two hemophilia A patients developed persistent high-titer FVIII inhibitors following AAV-mediated gene therapy with a bioengineered FVIII transgene despite prior extensive FVIII exposure.
This study illuminates how APOE ɛ4 accelerates executive function decline while ɛ2 may protect verbal episodic memory in individuals aged 90+, highlighting genetic influences on cognition in exceptional longevity.