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This randomized controlled trial evaluates how patient-specific 3D-printed temporal bone models influence surgeon cognitive load during cochlear implantation, revealing experience-dependent benefits for attendings and challenges for trainee
This study elucidates how distinct patterns and gradations of vascular invasion in hepatocellular carcinoma differentially impact recurrence timing and overall survival, enabling improved postoperative risk stratification.
A validated nomogram predicts hypothyroidism risk within 12 months after hemithyroidectomy using clinical and pathological variables, aiding tailored patient counseling and postoperative monitoring.
This study elucidates transcriptomic differences between primary gastric cancers and peritoneal metastases, revealing distinct tumor microenvironments and molecular pathways, highlighting potential targets for improved diagnosis and therapy
This review synthesizes evidence from recent randomized controlled trials assessing negative pressure therapy (NPT) for reducing wound complications after major lower extremity amputation, highlighting variable efficacy and potential benefi
This study finds no association between objectively measured maternal supine sleep during late pregnancy and customised birthweight centiles, suggesting mechanisms other than fetal growth underlie the risk of stillbirth with supine sleep po
This article evaluates a novel laparoscopic technique combining neovaginoplasty and uterovaginal anastomosis to restore menstrual function in cervicovaginal agenesis with functional uterine remnants, highlighting its feasibility and challen
In women with chronic hypertension, fetal growth restriction at 35-36 weeks gestation predicts higher progression to superimposed preeclampsia, underscoring the need for targeted maternal-fetal surveillance.
This study classifies preterm prelabor rupture of membranes (PROM) into four intra-amniotic types, detailing differences in gestational age distribution, microbial profiles, and neonatal outcomes, highlighting risks associated with infectio
Scheduled vibrator use combined with educational support significantly improves sexual function in women with sexual dysfunction and pelvic floor disorders compared to education alone.
This article summarizes ACOG’s 2026 Committee Statement on the Pregnant Workers Fairness Act, explains clinician roles in documentation and accommodation, and outlines practical recommendations for obstetric care.
This article explores how genetic variants affect CPEB3-mediated alternative polyadenylation in hepatocellular carcinoma, revealing potential prognostic markers and therapeutic targets to improve patient survival.
A comprehensive multinational study reveals that achalasia significantly raises the risk of esophageal squamous cell carcinoma independently, while its association with adenocarcinoma is modest and largely mediated by gastroesophageal reflu
A randomized controlled crossover trial found that individualized exclusion diets based on confocal laser endomicroscopy (CLE) findings do not significantly improve symptoms in irritable bowel syndrome (IBS) patients compared to sham diets.
This study evaluates differential item functioning in the EQ-5D-5L questionnaire among acute ischemic stroke patients, revealing minimal impact of age-related biases on quality of life measurement across sex and treatment groups.
This article details how BCKDK, a hypoxia-induced kinase, disrupts branched-chain amino acid metabolism to worsen neuronal injury in cerebral ischemia, highlighting its potential as a novel therapeutic target.
Elevated plasma p-tau217 correlates with cognitive impairment and altered sleep microarchitecture in older adults with late-onset unexplained epilepsy, highlighting potential pathways linking neurodegeneration, epilepsy severity, and sleep
Longitudinal analysis of blood proteins reveals distinctive trajectories and associations with cognitive decline in adults with Down syndrome, shedding light on Alzheimer’s disease pathophysiology in this high-risk group.
The STRATEGY trial assessed whether combining tirofiban with aspirin improves outcomes in branch atheromatous disease (BAD)-related stroke but found no significant benefit over aspirin alone in preventing neurological deterioration or recur
This review synthesizes recent evidence demonstrating guanabenz’s manageable safety profile and efficacy in delaying ambulatory decline in early-onset vanishing white matter disease, highlighting translational pharmacokinetic data and
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