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This retrospective study compares oncologic and perioperative outcomes of minimally invasive radical hysterectomy without uterine manipulator versus open radical hysterectomy in early-stage cervical cancer, showing comparable survival but i
Large-scale proteomic analysis identifies novel maternal plasma protein biomarkers that improve detection of fetal death beyond established markers, highlighting both shared and unique pathological pathways with preeclampsia.
Vulvar cancer exhibits significant recurrence rates, predominantly local, with survival declining sharply after recurrence. Awareness of recurrence-associated symptoms enhances early detection. Surgery remains pivotal in management, with fr
Excessive supragastric belching (SGB) occurs in nearly 20% of patients with conclusive gastro-oesophageal reflux disease, contributing significantly to acid exposure time and symptom burden. This multicentre study identifies clinical predic
This study analyzes global trends comparing ischemic stroke burdens linked to diabetes and atrial fibrillation, revealing a rising impact of diabetes-related stroke and highlighting the need for targeted interventions.
This review explores evidence linking smoking and exhaled carbon monoxide levels to reduced Parkinson’s disease risk, emphasizing a potential protective role of carbon monoxide, supported by recent large-scale cohort data and biologic
This study links MC1R loss-of-function variants to faster motor decline and phenoconversion in Parkinson’s disease, suggesting their value for prognosis and clinical trial design in European descent patients.
This review examines the role of FreeStyle Libre Pro iQ CGM in differentiating presymptomatic stages of type 1 diabetes and predicting progression to clinical disease, comparing its performance with Dexcom G6 and discussing implications for
This article explores the unique challenges autistic transgender and gender diverse adults face in adhering to gender-affirming hormone therapy (GAHT) and highlights strategies to support effective therapy adherence in clinical endocrinolog
This study reveals that individuals with Congenital Adrenal Hyperplasia (CAH) experience early, frequent, and complex hospitalizations with higher risk of severe outcomes, especially in infancy, compared to non-CAH patients, emphasizing the
This cohort study links polygenic scores for macronutrient intake with specific food choices in children and adolescents, highlighting genetic pathways involving hypothalamic appetite regulation but limited effects on cardiometabolic outcom
A study reveals a significant secular increase in islet autoimmunity incidence among Colorado children from 1993 to 2010, particularly in those with moderate-risk HLA genotypes, highlighting evolving risk profiles beyond known environmental
This review synthesizes evidence linking aspirin use to reduced risk of calcific aortic valve disease in persons with elevated lipoprotein(a), highlighting the potential for targeted preventive strategies.
The LIFE-Preserved model accurately predicts short-term and lifetime risks of heart failure hospitalization or cardiovascular death in HFpEF patients, enabling tailored clinical risk stratification and improved management.
Chronic exposure to fine particulate matter (PM2.5) is linked to epicardial coronary endothelial dysfunction, an early marker of coronary artery disease, as demonstrated by invasive coronary vasoreactivity testing.
The FAVOR III China trial demonstrates that QFR-guided percutaneous coronary intervention significantly reduces major adverse cardiac events over 5 years, mainly by decreasing myocardial infarction and ischemia-driven revascularization comp
Integration of late gadolinium enhancement corridors and high-risk genotypes markedly improves ventricular arrhythmic risk prediction beyond traditional ejection fraction metrics in nonischemic dilated cardiomyopathy.
Macrotroponin complexes commonly cause discordant cardiac troponin elevations in the general population, notably troponin I, without conferring increased cardiovascular risk, underscoring the need to recognize assay interference for accurat
An integrated educational and structural intervention in an internal medicine residency clinic improved residents’ confidence and timely communication of test results, highlighting the importance of aligning education and clinical sys
This review synthesizes emerging evidence demonstrating robust effectiveness of RSV vaccination in reducing hospitalization, death, and severe outcomes among elderly nursing home residents during the vaccine’s inaugural season.
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