Our website uses essential cookies and, with your consent, additional cookies to measure performance and improve our services. Cookie Policy.
You can change your choice at any time.
This phase 3 trial found that ecopipam reduced tic relapse and maintained symptom improvement in children and adolescents with Tourette syndrome, with mainly central nervous system side effects and no major weight or metabolic concerns.
A Circulation study identifies MAML1 as a candidate congenital heart disease gene and shows that defective phase separation in endocardial cells suppresses Notch signaling, impairing endocardial-to-mesenchymal transition and causing septal
A small pilot study found that busulfan-based haploidentical stem cell transplantation followed by dinutuximab beta was feasible and may improve long-term remission in very high-risk neuroblastoma.
In Puerto Rican youth, an unhealthy diet was linked to higher odds of T17-high asthma, suggesting diet may influence asthma through immune pathways beyond allergy-related inflammation.
A large-scale Dutch cohort study reveals that women with a history of spontaneous preterm birth face a significantly elevated risk of cardiovascular mortality, with the highest risk observed in those delivering before 32 weeks of gestation.
A Japanese multicenter registry study suggests ECPR may improve 1-month survival and neurologic outcomes in selected children with out-of-hospital cardiac arrest, although estimates were imprecise and residual confounding remains a major li
In selected children with out-of-hospital cardiac arrest, extracorporeal CPR was associated with higher one-month survival and better neurologic outcomes than continued conventional CPR, though the study was observational and estimates were
In 180 adolescents and young adults with childhood-onset GH deficiency, glucagon-stimulated GH secretion was driven mainly by hypothalamic-pituitary disease severity, while BMI had little independent effect after accounting for etiology.
A nationwide Danish cohort study found rapid growth in infant frenotomy, wide municipal variation, and rare severe complications, raising questions about clinical appropriateness in the setting of limited evidence for benefit.
A single-center retrospective study of 399 pediatric airway surgery patients found no significant adverse events clearly linked to postoperative nebulized ciprofloxacin-dexamethasone, supporting short-term safety while leaving efficacy and
A new study suggests vamorolone may preserve motor benefits seen with standard steroids in Duchenne muscular dystrophy while better protecting growth, though weight gain remains a concern.
In a stepped-wedge trial across 18 US centers, a pediatric GI surgery enhanced recovery protocol did not improve length of stay overall, but patients receiving at least 13 protocol elements had shorter stays, fewer complications, faster die
Children born SGA receiving growth hormone showed insulin resistance and prediabetes rates similar to obesity, suggesting the need for careful glucose monitoring during and after treatment.
Children with obesity and severe OSA usually stay overnight after tonsillectomy, but this study found most had no major complications. Oxygen nadir and AHI may help identify very low-risk patients who could be considered for same-day discha
Single-cell RNA sequencing suggests that childhood poverty exposure is associated with steroid-resistance signatures in leukemic blasts and adverse immune remodeling at diagnosis in standard-risk B-ALL.
This review evaluates 30 years of clinical outcomes for monocular congenital cataracts, revealing stagnant visual acuity results, high surgical burdens, and significant rates of secondary glaucoma and nystagmus despite surgical advances.
The Amblyopia Navigator offers evidence-based guidance for eye care professionals to improve early detection and treatment of childhood amblyopia, addressing specialist shortages through accessible digital tools.
New expert recommendations guide glucocorticoid dose reduction in pediatric classic CAH patients using crinecerfont, prioritizing normal growth while minimizing long-term steroid complications.
Registry data from 55,028 youths with type 1 diabetes show common LDL hypercholesterolemia, infrequent lipid-lowering therapy, and poor attainment of recommended LDL targets.
In a prospective multicenter evaluation, the EXCOR Active Driver supported pediatric VAD care with no major device malfunctions and excellent short-term survival, while addressing a major unmet need in mobility and day-to-day function.
Open language-specific specialty feeds and department pages.