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This review synthesizes evidence from the ARTEMIS trial and related studies on community-based adolescent mental health care and stigma reduction, highlighting intervention efficacy, implementation challenges, and translational potentials i
A comprehensive multicenter study reveals that ovarian immature teratomas with microscopic yolk sac tumor foci in pediatric patients have favorable outcomes, showing no increased recurrence risk despite higher tumor grade and stage.
This study reveals that IL-10-neutralising autoantibodies occur in 2.1% of pediatric IBD cases without monogenic causes, persist over years, and may define a distinct clinical subgroup with specific therapeutic needs.
A phase 3 randomized, placebo-controlled crossover trial demonstrates that levacetylleucine significantly improves neurological function in ataxia-telangiectasia patients with a favorable safety profile.
This study reveals that most emergency departments rarely encounter critically ill children, and only a minority of these cases could be redirected to high-volume centers, challenging the feasibility of universal direct transport policies f
A large sibling-matched cohort study found no link between prenatal acetaminophen exposure and autism or ADHD, suggesting prior associations were confounded by familial factors and supporting the safety of indicated paracetamol use during p
Early life stress disrupts gut motility and pain regulation via enteric and sympathetic nervous system alterations, with human pediatric data confirming its clinical relevance and suggesting novel therapeutic targets.
A population-based study reveals a significant reduction in impaired awareness of hypoglycemia and severe hypoglycemia in youth with type 1 diabetes from 2002 to 2024, indicating substantial progress in diabetes care and the ongoing need fo
The novel Python-based tool PEPPER enhances electronic medical record searches, efficiently identifying youth with ketosis-prone diabetes, and dramatically reducing manual chart review time without compromising accuracy.
This review synthesizes 20 years of data on pediatric hyperthyroidism, highlighting shifts toward prolonged antithyroid drug therapy, reduced definitive treatments, and rising relapse rates, underscoring the need for individualized long-ter
A longitudinal blood gene-expression study in children found an early neutrophil-driven immune pattern at age 1, followed by a persistent eosinophilic signature from 4.5 to 10.5 years in those who later developed asthma.
Preoperative cardiac testing in children with very severe OSA had low diagnostic yield and rarely changed management. Risk appeared highest in obese adolescents with AHI >50 events/hour.
In 187 fetuses with open spinal dysraphism, prenatal motor level was more caudal than the anatomical level in 85% of cases, with larger gaps in myeloschisis and higher lesions.
Prenatal ultrasound in open spinal dysraphism often underestimates functional level: in 85% of fetuses, motor level was more caudal than anatomy. Lesion type and height influenced the gap, with implications for counseling and fetal care pla
A modified Delphi study reached regional consensus on the most important outcomes and measurement tools for pediatric stroke rehabilitation, highlighting practical ways to standardize care and research across Australasia.
A 2026 Gastroenterology study links PRDM9 deficiency to ectopic DNA breaks, mosaic promoter deletions, and impaired enteric neuronal differentiation in sporadic Hirschsprung disease, while introducing a blood-based molecular score that impr
In a prospective multicenter study, the EXCOR Active Driver demonstrated excellent reliability and high short-term survival in children requiring ventricular assist support, while supporting a registry-enabled pathway for class III pediatri
In very preterm infants, thicker retinal nerve fiber layer on OCT at 36 weeks’ postmenstrual age was associated with better motor and cognitive outcomes at 2 years, supporting retinal imaging as a potential early neurodevelopmental biomarke
An Australian cohort study found that prenatal exposure to valproate, levetiracetam, topiramate, and carbamazepine was associated with poorer cognitive outcomes in children, while lamotrigine exposure was not.
Immune checkpoint therapy has become a major advance in pediatric Hodgkin lymphoma and is now being actively tested across selected pediatric non-Hodgkin lymphomas with strong PD-L1 biology.
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