Section
A multidisciplinary consensus provides practical, trial-design focused recommendations for testing systemic therapies around surgery or combined with locoregional treatment in hepatocellular carcinoma, emphasizing patient selection, endpoin
Butyrylcholinesterase (BuChE) modulates hepatic stellate cell activation by degrading acetylcholine, mitigating fibrogenesis via muscarinic receptor signaling and offering a new therapeutic target for liver fibrosis.
In a large Dutch cohort, 90% of patients with Barrett’s esophagus-related dysplasia or cancer had no prior endoscopic surveillance, highlighting a critical gap in early detection and the need for evidence-based screening strategies.
This multinational study reveals that specific gut microbiome profiles significantly correlate with 90-day hospitalisation risk in cirrhosis, enhancing prognostic accuracy beyond clinical features alone.
This study integrates multi-omics data to characterize steatohepatitic hepatocellular carcinoma (SH-HCC), establishing robust diagnostic models and identifying FABP4 as a promising therapeutic target, with implications for personalized mana
The PORTOLA phase 2a trial evaluates zetomipzomib, a selective immunoproteasome inhibitor, demonstrating numerically improved biochemical remission and steroid-sparing effects in autoimmune hepatitis patients with inadequate response to sta
This review synthesizes evidence demonstrating disrupted gastrointestinal interoception in weight-restored anorexia nervosa, linking behavioral and neural disturbances with relapse risk and symptom severity, and highlighting novel mechanist
This review assesses the clinical utility of steatotic liver disease risk scores in predicting cirrhosis and hepatocellular carcinoma, highlighting the superior performance of the SAFE score for cirrhosis and challenges in HCC risk predicti
High expression of neurotensin receptor 1 (NTSR1) defines an immune-cold colorectal cancer subtype linked to worse outcomes by creating mechanical and biological barriers that exclude T-cell infiltration, highlighting a novel immunotherapeu
This review synthesizes evidence on the predictive and pathogenic roles of gut phages and bacterial resistomes in necrotising enterocolitis, highlighting divergent mechanisms for early- versus late-onset disease and translational opportunit
The RADICAL consortium’s large-scale study reveals a high long-term transition rate from immune tolerant to immune active chronic hepatitis B, especially in patients with high-normal ALT, suggesting the need for closer monitoring and
The LiveSMART trial demonstrates that lactulose, with or without sequential TeleTai-Chi, significantly reduces fall risk and related harms in cirrhotic patients without prior overt hepatic encephalopathy.
This longitudinal study reveals that gut microbiome remodeling during immune checkpoint inhibitor therapy in advanced liver cancer patients predicts clinical benefit, improving biomarker accuracy and survival stratification.
A recent double-blind, placebo-controlled trial found that non-enteric-coated pancreatic enzyme therapy does not significantly reduce pain in chronic pancreatitis patients, highlighting the need to revisit pain management strategies in this
This article reviews advances in liver xenotransplantation using genetically modified porcine organs as a bridging strategy for acute liver failure, highlighting recent clinical progress, challenges, and future directions.
This study elucidates how intestinal blood vessel-associated macrophage dysfunction contributes to gut-vascular barrier breakdown and bacterial translocation in cirrhosis, revealing novel mechanisms that underlie systemic infection risks in
A Swedish national retrospective study reveals that liver transplantations initiated between 17:00 and 05:59 are linked to significantly increased postoperative complications and healthcare costs, highlighting the need for optimized schedul
VPS13D protects against alcohol-induced liver injury by maintaining mitochondria-ER contact sites, regulating phospholipid balance and promoting VLDL secretion, thus mitigating steatosis and inflammation in alcoholic hepatitis.
This study reveals that TL1A-activated CD4+ T cells drive distinct cellular and molecular changes in the rectal mucosa of Crohn’s disease patients with perianal fistulising disease (PFD), highlighting a novel TL1A-LTα1β2/IL-22 axis in
This meta-analysis of four RCTs compares cold and hot snare polypectomy for large colorectal polyps, demonstrating lower major adverse events but higher recurrence with cold resection, especially in adenomas with high-grade dysplasia.
