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This study delineates three unique molecular subtypes of cholangiocarcinoma via integrated multiomic and machine learning methodologies, highlighting TNK1 kinase as a promising targeted therapy in a metabolic subtype.
NSUN6 deficiency in pancreatic cancer promotes immune suppression by enhancing immunosuppressive macrophage infiltration via the KDM5A-CCL2 axis, leading to resistance to immune checkpoint blockade; targeting this pathway offers a promising
Flagellated gut bacteria activate TLR5 on neutrophils, triggering IL-15 release and macrophage arachidonic acid production, driving systemic inflammation in long COVID, rheumatoid arthritis, ankylosing spondylitis, and IBD.
This study reveals that weight gain exceeding 5% in MASLD patients increases liver-related event risks and liver stiffness, whereas weight loss improves liver stiffness and may reduce adverse outcomes, especially with obesity reversal.
Researchers unveil ciliogenic pancreatopathy, a new pancreatic disease connected to ciliary gene mutations, highlighting its clinical significance in patients with syndromic ciliopathies and kidney dysfunction.
This study reveals the pivotal role of WISP1 in driving intestinal fibrosis in Crohn’s disease through fibroblast metabolic shifts and cytoskeletal remodeling, suggesting WISP1 neutralization as a novel antifibrotic intervention.
Epigenetic repression of hepatocyte FoxO1 disrupts immune homeostasis in the liver, promoting inflammation via altered NKT cell regulation, revealing promising therapeutic targets for inflammatory liver diseases.
Emerging evidence identifies circulating imidazole propionate, a gut microbiota-derived metabolite, as an independent predictor of major adverse cardiovascular events in patients with coronary artery disease, offering novel insights into pe
Low-frequency repetitive transcranial magnetic stimulation targeting the medial prefrontal cortex reduces visceral pain and improves bowel symptoms in IBS-D by normalizing central neural hyperexcitability.
This multicenter study reveals that pruritus affects one in four patients with primary sclerosing cholangitis (PSC), persists over time, and correlates with disease severity, underscoring its clinical significance and guiding future therape
AHB-137, an antisense oligonucleotide targeting HBV mRNA, demonstrated safety, favorable pharmacokinetics, and rapid HBsAg reduction in healthy volunteers and chronic hepatitis B patients, supporting further clinical development.
Cryptogenic steatotic liver disease (SLD), representing a lean phenotype without classic cardiometabolic risk factors, is associated with adverse liver profiles and higher liver-related mortality, highlighting an underrecognized high-risk s
Shear wave elastography (SWE) shows comparable accuracy to vibration-controlled transient elastography (VCTE) for stratifying liver-related event risk in MASLD patients using FIB-4-based two-step algorithms.
Cryptogenic steatotic liver disease (SLD) is a form of fatty liver disease found in lean individuals without diabetes or other metabolic risk factors, associated with significant liver injury and increased mortality risk.
The ENIGMA study reveals altered metabolism of the emulsifier polysorbate-80 and elevated artificial sweeteners in Crohn’s disease, linking these dietary additives to disease activity and potential biomarker development.
This article reviews evidence linking cardiovascular-kidney-metabolic syndrome stages to liver fibrosis severity, progression, and liver-related events in metabolic dysfunction-associated steatotic liver disease (MASLD). Higher CKM stages i
This prospective study confirms that liver stiffness measurement (LSM) by Fibroscan® effectively predicts transplant-free survival in primary sclerosing cholangitis (PSC), highlighting both static and dynamic assessments as powerful risk st
A multicategory study reveals 2.5% of pediatric IBD patients harbor IL-10-neutralising autoantibodies associated with severe disease and HLA-DRB1*01:03 allele, underscoring a distinct pathogenic subgroup.
Cirrhosis entwined with diabetes presents unique clinical challenges. This article offers a pragmatic framework for diagnosis, tailored therapies, and multidisciplinary care to enhance outcomes across liver disease stages.
This review synthesizes evidence on statin therapy reducing hepatic decompensation and major adverse liver outcomes in primary biliary cholangitis, highlighting a recent robust target trial emulation study across diverse populations.
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