Clinical Utility of a 30% Reduction in VCTE-Derived Liver Stiffness Measurement for Identifying Histologic Improvement in Metabolic Dysfunction-Associated Steatohepatitis
Highlights
- A ≥30% relative decline in VCTE-derived liver stiffness measurement (LSM) is modestly predictive of histologic fibrosis regression in MASH patients.
- This non-invasive marker aligns with regulatory recommendations but shows only moderate diagnostic accuracy (AUC ~0.65), underscoring the need for complementary biomarkers.
- Multivariable-adjusted analyses confirm the independent association between ≥30% LSM reduction and fibrosis improvement without worsening steatohepatitis.
- Validation across diverse cohorts reveals consistent but limited performance, indicating population heterogeneity and measurement variability.
Background
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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.