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Despite proven benefits, medications for alcohol use disorder remain underprescribed at hospital discharge. This study identifies hospitalization and patient factors influencing new prescriptions, highlighting opportunities to enhance AUD t
A novel thrombin-cleavable FVIII-mimetic antibody enables dynamic, on-demand control of coagulation, reducing adverse thrombotic risk while maintaining efficacy in hemophilia A treatment.
This study identifies key organizational, social, and individual determinants affecting lung cancer screening follow-up in community settings, highlighting strategies to improve adherence and optimize mortality benefits.
A cohort study identifies key risk factors such as faster baseline visual field loss, higher post-progression intraocular pressure, and older age that predict recurrence of visual field progression in glaucoma, emphasizing the need for pers
This study evaluates how users of hearing aids and cochlear implants perceive musical sound quality when low-frequency components are degraded, revealing significant differences in sensitivity relevant to patient counseling and device optim
This study analyzes the incidence and clinical consequences of pancreatic fistulas and intra-abdominal fluid collections following distal pancreatectomy, highlighting their management and the impact of surgical drain placement.
A New Zealand RCT demonstrates that self-assessment with low sensitivity urine pregnancy tests after early medical abortion improves complete follow-up and successful abortion rates compared to serum bhCG testing, supporting safer, equitabl
This phase 1b study of miricorilant, a selective glucocorticoid receptor modulator, shows significant reductions in liver fat and improvements in liver health markers in patients with presumed metabolic dysfunction-associated steatohepatiti
This review synthesizes evidence from the PROOF-HD placebo arm and related studies, demonstrating that antidopaminergic medication use in Huntington disease correlates with accelerated decline in functional, motor, and cognitive outcomes, e
This phase 2 trial demonstrates that once-weekly lonapegsomatropin matches daily somatropin in improving height velocity and safety in children with Turner syndrome over 52 weeks, offering a promising alternative to daily injections.
Initiating cholesterol-lowering therapy during childhood in familial hypercholesterolaemia substantially reduces LDL-C burden and cardiovascular risk, highlighting the importance of early diagnosis and treatment.
An 8-week smartphone-based digital therapeutic offering personalized exercise and cognitive-behavioural therapy significantly improved pain, knee function, quality of life, and psychological outcomes in patients with chronic patellofemoral
A clinician-led computer vision system enables accurate, feasible, and usable postural assessment in acquired brain injury rehabilitation, demonstrating significant alignment with clinical evaluations and motion capture data.
CaneStat, a recombinant hybrid protein, uniquely modulates enamel pellicle properties fostering increased resistance to early enamel erosion, as evidenced by biophysical and clinical assessments.
Sacituzumab tirumotecan combined with pembrolizumab significantly improves progression-free survival in PD-L1-negative advanced nonsquamous NSCLC compared to chemotherapy plus pembrolizumab, offering a promising new treatment standard with
This feasibility RCT demonstrates that the HOPE4ABI digital intervention is acceptable and beneficial for improving mental, sexual wellbeing, and quality of life in stroke and brain injury survivors, warranting a definitive efficacy trial.
A cost consequence analysis demonstrated that guided periodontal infection control (GPIC) is less costly than conventional non-surgical therapy (CNST) while achieving similar periodontal health outcomes at six months.
The PRABITAS trial demonstrated that a 14-day trifluridine-tipiracil plus bevacizumab regimen is non-inferior to the conventional 28-day schedule in refractory metastatic colorectal cancer, with significantly reduced hematological and gastr
PHH-1V, a protein-based COVID-19 vaccine, is shown to be a safe and effective heterologous booster in adolescents, generating strong and lasting immune responses against multiple virus variants.
This article explores distinct immune cell activations in ACPA-positive individuals progressing to rheumatoid arthritis, emphasizing type I interferon activity prior to ultrasound-detectable synovitis and subsequent inflammatory shifts mark
