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The AZALEA-TIMI 71 study demonstrates that factor XI inhibition with abelacimab reduces bleeding risk in atrial fibrillation patients regardless of prior oral anticoagulation experience, with a potentially greater absolute benefit in antico
A randomized trial shows reperfusion-guided blood pressure management post-thrombectomy improves functional outcomes and reduces hemorrhagic transformation, supporting personalized BP targets based on reperfusion status.
Elevated endogenous insulin and insulin resistance independently predict progression of diastolic dysfunction and increased cardiovascular mortality, highlighting early metabolic dysregulation as a target to prevent heart failure with prese
This review synthesizes recent evidence on adult subvalvular aortic stenosis, highlighting long-term clinical outcomes, disease progression, and implications for management and follow-up strategy.
This phase 3 trial demonstrates that the oral PCSK9 inhibitor enlicitide achieves significantly greater LDL-C reduction than bempedoic acid, ezetimibe, or their combination in statin-treated adults at elevated cardiovascular risk, with comp
This study reveals that two-thirds of community sudden cardiac deaths occur in individuals without diagnosed cardiac disease, with half harboring occult myocardial infarction or dilated cardiomyopathy, underscoring the need for improved det
Expedited discharge (≤4 days) following isolated coronary artery bypass grafting is linked to shorter hospital stays, lower costs, and reduced 30-day readmissions without increased mortality or major complications, supporting selective impl
This study elucidates how uterine artery Doppler at 35-36 weeks reflects placental angiogenic imbalance and hemodynamic dysfunction in preeclampsia, underscoring its biological relevance beyond early pregnancy screening.
This pilot randomized trial demonstrates the feasibility of using low-dose colchicine after acute intracerebral hemorrhage to prevent vascular events, highlighting considerations for future larger studies regarding recruitment, adherence, a
In a nationwide case-control study, adults with congenital heart disease had similar 1-year mortality and recurrent heart attack rates after a first acute myocardial infarction as matched controls. A higher 10-year mortality estimate did not persist after adjustment, supporting aggressive cardiovascular risk-factor management.
This meta-analysis of four placebo-controlled trials reveals no significant difference in the efficacy and safety of mineralocorticoid receptor antagonists between Black and non-Black patients with heart failure, regardless of heart failure
Highlight Deep learning applied to 12-lead ECG signals enables estimation of 10-year ischemic stroke risk with moderate discrimination and good calibr
Highlight This unprecedented large-scale multinational study developed a semisupervised contrastive machine learning framework that generates a global
Registry-based randomised controlled trials (RRCTs) offer promising efficiencies and external validity over traditional RCTs, yet lack consistent definitions and registration standards. A proposed taxonomy and adherence to CONSORT-ROUTINE a
This review synthesizes contemporary evidence on the survival impact of adding defibrillators to CRT in nonischemic cardiomyopathy, highlighting heterogeneous results including the DECIDE-CRT study and underscoring the need for personalized
A large Chinese cohort study reveals a U-shaped association between left ventricular end-diastolic diameter and mortality in heart failure, highlighting both small and large ventricular sizes as independent risk factors.
This propensity-matched study shows that in patients undergoing tricuspid TEER for severe TR, untreated moderate MR is linked to worse survival, while combined mitral and tricuspid TEER improves mortality and functional outcomes, highlighti
In low-risk severe aortic stenosis patients, both TAVR and SAVR provide sustained health status improvements over seven years, with TAVR offering faster early recovery but similar long-term health outcomes.
This study reveals that left ventricular hypertrabeculation, common in dilated cardiomyopathy, does not increase embolic risk or adverse outcomes, challenging previous concerns and guiding clinical management.
A race-free adaptation of the MESA risk score estimates 10-year coronary heart disease risk with comparable accuracy to the original, challenging the necessity of including race/ethnicity in cardiovascular risk prediction.
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