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The PELICAN trial found that individualized cardiac index-guided intraoperative hemodynamic therapy did not reduce major postoperative complications compared to routine care in high-risk major abdominal surgery patients.
A virtual aerobic exercise program significantly improves recovery speed and quality of life in youth with prolonged concussion, especially when initiated within three months of injury, outperforming stretching interventions.
A real-world Japanese study finds comparable 24-month treatment persistence between reduced and standard dosing of JAK inhibitors in rheumatoid arthritis patients with preserved renal function, with dose considerations influenced by poor pr
A novel nomogram using pretransplant triglycerides and body weight shows promise to guide early mycophenolate mofetil dosing after kidney transplantation, potentially reducing drug overexposure before therapeutic drug monitoring is feasible
An international expert consensus provides the first pediatric‑specific framework for low‑dose oral minoxidil (LDOM) in children aged 4–11 years: indications, dosing strategies, safety checks, monitoring, contraindications, and long‑term us
J-scar mammaplasty offers a safe, versatile level 2 oncoplastic technique with favorable aesthetic and oncologic outcomes, validated in a 157-patient study with low complication rates and high satisfaction.
A pooled analysis from the PRIME database reveals distinct ventilatory management patterns and ARDS incidence in neurocritical versus non-neurocritical patients, highlighting key associations between ventilator settings and outcomes.
This study examines how effective patient-centered communication by physicians at community health centers supports self-management behaviors in patients with cardiometabolic conditions.
Targeting the mitochondrial complex I subunit NDUFS2 enhances sensitivity to FLT3 inhibitors and overcomes drug resistance in acute myeloid leukemia with FLT3-ITD mutations, suggesting a promising therapeutic strategy.
This review explores barriers and facilitators influencing research participation among Black and Hispanic/Latino(a) individuals with cystic fibrosis (CF), highlighting systemic inequities, racialized experiences, and community-centered sol
A large-scale phenotypic screen of 9,139 knockout mouse lines identified 18 candidate genes linked to retinal and hearing abnormalities, offering promising new targets for understanding and diagnosing Usher syndrome.
Free mucosal grafting on the contralateral side during nasal septal perforation repair enhances healing, achieving over 90% anatomical closure with rapid re-epithelialization and improved nasal symptoms.
This study explores how microbiome compositions differ in patients with foregut anastomotic leaks managed endoscopically versus surgically, highlighting nutrition and microbial patterns as key factors influencing healing.
This study reveals bidirectional mediation between BMI and inflammatory markers affecting embryo quality and availability in PCOS women undergoing ART, highlighting BMI’s predominant role.
This study reveals that younger, non-Hispanic White patients with fewer comorbidities and lower socioeconomic vulnerability are more likely to receive antiamyloid medications for Alzheimer’s, while higher comorbidity predicts lower initial
This study demonstrates that reducing radiation fields in advanced differentiated thyroid carcinoma lowers toxicity without compromising locoregional tumor control, supporting personalized radiotherapy strategies.
Quadriceps strength recovery after ACL reconstruction exhibits three distinct trajectories linked to preoperative strength and meniscectomy status, yet these trajectories do not correlate with postoperative clinical outcomes at one year.
A feasibility RCT demonstrates that a telehealth-delivered behaviour change intervention, augmented with a physical activity monitor, can increase physical activity in post-stroke individuals, supporting future large-scale trials.
A comprehensive assessment of the teaching practices regarding repair and replacement of defective composite restorations in Canadian dental schools highlights the move towards minimally invasive dentistry and calls for harmonization of edu
Fractional doses (one-fifth and one-half) of 17DD yellow fever vaccine demonstrate non-inferior immunogenicity and comparable safety to full doses in children aged 9–23 months, supporting dose-sparing strategies during vaccine shortages.
