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RESTORE II RCT demonstrates that a 12-week multidisciplinary rehabilitation program significantly improves cardiorespiratory fitness in survivors of upper gastrointestinal cancer surgery, supporting its integration in post-oncologic care.
This study compares long-term outcomes of endovascular versus open bypass interventions for femoropopliteal disease in patients with claudication, finding similar rates of major adverse limb events and progression to critical limb ischemia
This study reveals the population prevalence and incident risk of HPA-1a alloimmunisation in pregnancy across diverse ethnic groups, highlighting its rarity and establishing a framework for risk assessment in foetal-neonatal alloimmune thro
This secondary analysis of the REPAIR study identifies prolonged active second stage labor, deep tears, and physician involvement in suturing as risk factors for perineal wound complications, while prophylactic antibiotics reduce this risk.
This study reveals that CLDN18.2 acquired by CD8+ T cells through trogocytosis impairs their glucose metabolism and cytotoxic function, promoting pancreatic cancer progression and systemic immune senescence. Targeting this axis may enhance
This UK cohort study reveals that both maternal and paternal obesity before pregnancy significantly increase offspring’s risk of metabolic dysfunction associated steatotic liver disease (MASLD) by age 24, largely mediated by excess ch
This comparative analysis assesses ischemic stroke outcomes in patients with asymptomatic carotid stenosis undergoing transcarotid artery revascularization (TCAR) versus carotid artery stenting (CAS), highlighting no significant difference
This review synthesizes longitudinal evidence linking early adulthood vascular risks, particularly elevated systolic blood pressure and smoking, to midlife cognitive decline and brain structural alterations. It highlights critical intervent
This large-scale England study reveals persistently high mortality after below-knee amputation in diabetes, with one-year mortality exceeding 23%, emphasizing the need for targeted interventions focused on older, female, and comorbid patien
The MYSTICS Registry provides robust data on cardiac sarcoidosis, highlighting diagnostic challenges, treatment patterns, and prognostic differences among phenotypes, emphasizing tailored management strategies to improve patient outcomes.
The TARGET-D trial investigated whether vitamin D supplementation, titrated to achieve serum levels >40-80 ng/mL, reduces major adverse cardiovascular events after myocardial infarction but found no significant benefit in the primary com
This article explores the integration of evidence-based medicine and personalized approaches in managing heart failure and inherited cardiomyopathies, proposing a framework to optimize patient care by harmonizing standardized guidelines wit
This randomized trial evaluates the safety and efficiency of the ESC 0/1-hour versus 0/3-hour high-sensitivity troponin pathways in suspected acute coronary syndrome, showing noninferior safety but no significant improvement in rapid discha
The BRIGHT-4 trial demonstrates that bivalirudin with prolonged infusion reduces 30-day mortality and major bleeding compared to heparin in STEMI patients undergoing radial primary PCI, benefiting both low and higher bleeding risk groups.
This study explores cardiac structural and functional changes over prolonged spaceflight and simulated Martian gravity, revealing transient adaptations that stabilize without lasting detrimental effects, suggesting effective cardiovascular
Recent research identifies intestinal serotonin 5-HT3a receptor signaling via vagal neurons as a key mediator of microbiota-induced hypertension, offering new insights into resistant hypertension and potential therapeutic targets.
A 12-week randomized trial compared the effects of calorie-restricted DASH, carbohydrate-restricted, and low-purine diets on weight loss and serum urate levels in men with overweight or obesity and hyperuricemia, highlighting adherence and
The CREST-2 trial substantiates carotid artery stenting plus intensive medical management significantly reduces stroke risk in high-grade asymptomatic carotid stenosis compared to medical therapy alone, emphasizing patient selection and pro
A recent randomized trial shows that adding intravenous immunoglobulin (IVIG) to high-dose prednisone significantly improves muscle strength and disease activity in newly diagnosed idiopathic inflammatory myopathies with rapid and clinicall
The effectiveness of lifestyle interventions promoting physical activity for diabetes risk reduction varies by prediabetes phenotype, with individuals having impaired fasting glucose showing the least response. Tailored approaches may enhan
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